{"id":"W1979040872","doi":"10.1074/jbc.m000621200","title":"Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Protein kinase C; Forskolin; Molecular biology; Biology; Phorbol; Protein kinase A; Kinase; Transcription factor; Response element; Chemistry; Cell biology; Gene expression; Biochemistry; Promoter; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489235,0.0003425389,0.0001818528,0.0002450688,0.0002272658,0.0003268032,0.0001430587,0.0001519727,0.001608852],"category_scores_gemma":[0.0001865224,0.0001374597,0.0003024799,0.0001931119,0.0002855198,0.0001920882,0.0001969366,0.0006335009,0.0004444751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005610636,"about_ca_system_score_gemma":0.0004152095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569751,"about_ca_topic_score_gemma":0.001984966,"domain_scores_codex":[0.9998344,0.00002159631,0.00001235979,0.00004580111,0.00005104229,0.00003476283],"domain_scores_gemma":[0.9998919,0.00002554223,0.0000185821,0.0000133933,0.00002511706,0.00002540908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460269,0.00002232954,0.0002414377,0.00003615001,0.000002980766,0.00003995005,0.00001604353,0.00002397034,0.9983262,0.00007912335,0.00004621915,0.001019552],"study_design_scores_gemma":[0.00003282558,0.0002615729,0.01054417,0.00001143263,0.00001560641,0.0002393142,0.00007063187,0.001519545,0.9844196,0.0001377987,0.002742072,0.000005335955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883751,0.002230652,0.005036031,0.0002651367,0.0001292942,0.00005984463,0.000691538,0.00009671988,0.003115867],"genre_scores_gemma":[0.9841602,0.001424745,0.006339722,0.00007638144,0.00005681049,0.00007564038,0.001288448,0.00001654532,0.006561427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608852,"threshold_uncertainty_score":0.005382121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528108154397414,"score_gpt":0.261382972895735,"score_spread":0.2361018913517609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}