{"id":"W1979100659","doi":"10.1152/ajpendo.00507.2009","title":"Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique","keywords":"Endoplasmic reticulum; Unfolded protein response; Endocrinology; Internal medicine; Lipid droplet; Inflammation; Flux (metallurgy); Biology; Cell biology; Phenylbutyrate; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390267,0.000299853,0.0002712661,0.0001451861,0.0001238204,0.0003327302,0.00006572541,0.0001449147,0.0009693585],"category_scores_gemma":[0.0000730386,0.00009980633,0.0002303784,0.0001764087,0.0001940416,0.0001792726,0.0001933597,0.0003858978,0.0002319242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002151416,"about_ca_system_score_gemma":0.0001909677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150059,"about_ca_topic_score_gemma":0.0009457245,"domain_scores_codex":[0.9998801,0.00003225305,0.00001212955,0.00002311983,0.00002588824,0.0000265503],"domain_scores_gemma":[0.9999309,0.000008621367,0.00001952944,0.000008881036,0.0000105212,0.00002164544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003200942,0.00002602907,0.0002881987,0.00003938467,0.000004703675,0.00006395574,0.00001278751,0.00001952285,0.9983628,0.00002977982,0.00001836372,0.0008142864],"study_design_scores_gemma":[0.00005378463,0.0006048391,0.02263117,0.0000141875,0.00002970536,0.0003270897,0.0001268064,0.0007085907,0.9735073,0.00007725054,0.001911846,0.000007590199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943591,0.002331659,0.001559397,0.0001174109,0.00003845429,0.00002265042,0.0002061185,0.00004941737,0.001315875],"genre_scores_gemma":[0.9938222,0.001996004,0.001773638,0.00008633578,0.00001673403,0.00002993763,0.0003210435,0.0000114058,0.001942775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009693585,"threshold_uncertainty_score":0.003242791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005592637143687386,"score_gpt":0.2276256468527326,"score_spread":0.2220330097090452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}