{"id":"W1979101966","doi":"10.1089/dna.2006.25.124","title":"High Levels of Oxidative Stress Globally Inhibit Gene Transcription and Histone Acetylation","year":2006,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute; Canada Research Chairs; Terry Fox Foundation; Cancer Research Society","keywords":"Biology; Transcription (linguistics); RNA polymerase II; Acetylation; Histone; Oxidative stress; Cell biology; RNA polymerase; RNA polymerase II holoenzyme; Transcription factories; Molecular biology; Gene expression; Promoter; Gene; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790153,0.0004158855,0.0003594408,0.0001566858,0.0001701037,0.000511537,0.000237713,0.0002289985,0.0008630139],"category_scores_gemma":[0.0002069427,0.00018697,0.0002954804,0.0001114149,0.0003680858,0.0002389079,0.0003520979,0.0004553187,0.000284471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128233,"about_ca_system_score_gemma":0.0001587651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005387389,"about_ca_topic_score_gemma":0.001011453,"domain_scores_codex":[0.9997966,0.00002604352,0.0000169932,0.00005294062,0.00006146393,0.00004587011],"domain_scores_gemma":[0.9997512,0.00004325531,0.00007702685,0.00004100599,0.00003611502,0.00005149286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005938228,0.00001171817,0.000470016,0.00001782437,0.000009121543,0.00001008885,0.000006174736,0.00005795964,0.99875,0.00006310736,0.00001069136,0.0005338744],"study_design_scores_gemma":[0.00000693466,0.0002195692,0.007002637,0.000003874231,0.00001503454,0.00007465052,0.0000327595,0.0004629515,0.9912903,0.000123813,0.0007634567,0.000004032368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898475,0.001959607,0.006584787,0.0001081573,0.00003089953,0.00001485075,0.0001675895,0.00006136818,0.001225176],"genre_scores_gemma":[0.9971123,0.000599392,0.001304456,0.00004890485,0.000009610148,0.00001094595,0.0002129982,0.00001400957,0.0006873771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008630139,"threshold_uncertainty_score":0.00288707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004944058868844715,"score_gpt":0.2051090485753978,"score_spread":0.2001649897065531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}