{"id":"W1979101966","doi":"10.1089/dna.2006.25.124","title":"High Levels of Oxidative Stress Globally Inhibit Gene Transcription and Histone Acetylation","year":2006,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute; Canada Research Chairs; Terry Fox Foundation; Cancer Research Society","keywords":"Biology; Transcription (linguistics); RNA polymerase II; Acetylation; Histone; Oxidative stress; Cell biology; RNA polymerase; RNA polymerase II holoenzyme; Transcription factories; Molecular biology; Gene expression; Promoter; Gene; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006055026,0.00009786317,0.0001249312,0.00002153216,0.00003726472,0.000006062858,0.00004814358,0.0001561588,0.000008455178],"category_scores_gemma":[0.000002703899,0.00009319295,0.00002530209,0.00002628347,0.0001110506,0.000002240826,0.00003455602,0.00003092248,4.859812e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007215827,"about_ca_system_score_gemma":0.00001507458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001043931,"about_ca_topic_score_gemma":0.00008591272,"domain_scores_codex":[0.9994559,0.0000316683,0.0001648062,0.0002079658,0.00002798355,0.0001117124],"domain_scores_gemma":[0.9997507,0.000004672936,0.00008703799,0.0000942921,0.00003799716,0.00002524002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002540438,0.00003540174,0.001268551,0.00001955292,0.00001096447,3.031736e-7,0.00003133388,0.00004796512,0.9957314,0.0009575985,0.00002844116,0.001843138],"study_design_scores_gemma":[0.0005809183,0.0002601348,0.01336583,0.000003622936,0.00001849972,0.000003852925,0.00003820216,0.0000871758,0.9836148,0.00110061,0.0008115663,0.0001147601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958808,0.001307787,0.001870724,0.00004516497,0.00006369481,0.00008356299,0.0002446143,0.000003790919,0.000499816],"genre_scores_gemma":[0.9974617,0.0003056681,0.001422872,0.00003408007,0.00006195498,0.000003125127,0.0005412554,0.000006854512,0.0001624912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01211652,"threshold_uncertainty_score":0.3800298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004944058868844715,"score_gpt":0.2051090485753978,"score_spread":0.2001649897065531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}