{"id":"W1979104207","doi":"10.1038/mi.2011.21","title":"The gp41 epitope, QARVLAVERY, is highly conserved and a potent inducer of IgA that neutralizes HIV-1 and inhibits viral transcytosis","year":2011,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Ontario HIV Treatment Network","keywords":"Transcytosis; Epitope; Virology; Gp41; Antibody; Immunology; Immunity; Biology; HIV vaccine; Neutralizing antibody; Vaccination; Immunization; Immunoglobulin A; Immune system; Immunoglobulin G; Endocytosis; Cell; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496151,0.0003381865,0.000244254,0.0002938647,0.0001846069,0.0003258646,0.0002333222,0.000381904,0.001184872],"category_scores_gemma":[0.0001983617,0.0001476883,0.0002152187,0.0001299441,0.0002649881,0.0002022738,0.0002667598,0.0006521092,0.0003583601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005472,"about_ca_system_score_gemma":0.0001309782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000207851,"about_ca_topic_score_gemma":0.0002032808,"domain_scores_codex":[0.9998333,0.00004499292,0.000008255186,0.00002208301,0.00003840932,0.0000529349],"domain_scores_gemma":[0.9998829,0.0000304833,0.00002432154,0.00002153997,0.0000131378,0.00002758384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009258617,0.00003541402,0.000135142,0.00001729382,0.000003383139,0.00003123978,0.000008281892,0.00005771488,0.9970831,0.0001173335,0.00004257004,0.00237592],"study_design_scores_gemma":[0.00003757423,0.0006824508,0.003336224,0.000004612179,0.00001102394,0.0005231839,0.00001024691,0.0002534572,0.9924098,0.00008709259,0.002640242,0.000004118012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933964,0.001628425,0.002500613,0.0001293928,0.00002623274,0.00003219127,0.0001152012,0.00009030814,0.00208118],"genre_scores_gemma":[0.9968689,0.0003635328,0.001003156,0.00004701591,0.00001882753,0.000008412568,0.0002151578,0.00001398212,0.001461059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184872,"threshold_uncertainty_score":0.003963828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352582711751503,"score_gpt":0.2339941921087472,"score_spread":0.1987359209335969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}