{"id":"W1979104207","doi":"10.1038/mi.2011.21","title":"The gp41 epitope, QARVLAVERY, is highly conserved and a potent inducer of IgA that neutralizes HIV-1 and inhibits viral transcytosis","year":2011,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Ontario HIV Treatment Network","keywords":"Transcytosis; Epitope; Virology; Gp41; Antibody; Immunology; Immunity; Biology; HIV vaccine; Neutralizing antibody; Vaccination; Immunization; Immunoglobulin A; Immune system; Immunoglobulin G; Endocytosis; Cell; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161048,0.0002545978,0.0004137506,0.0001181547,0.0003316629,0.00002013898,0.000238449,0.0003346631,0.0002131378],"category_scores_gemma":[0.00003249895,0.0001707399,0.00009628757,0.00009221218,0.00156802,0.0001063905,0.0001788348,0.0003610505,0.0001908273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002248508,"about_ca_system_score_gemma":0.0000724069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331586,"about_ca_topic_score_gemma":0.0001888884,"domain_scores_codex":[0.9982873,0.0003872381,0.0003293386,0.0003618704,0.00004633785,0.0005879063],"domain_scores_gemma":[0.9991791,0.0002366853,0.0001169314,0.0003461786,0.00007497126,0.00004609331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00289731,0.0006491166,0.05783629,0.00005278493,0.002688228,0.00005500424,0.006458011,4.567546e-8,0.8636712,0.004924709,0.002957506,0.05780983],"study_design_scores_gemma":[0.0042042,0.001234993,0.23533,0.00003142122,0.0001192422,0.0002335162,0.0006666059,6.50469e-7,0.7436715,0.0006647526,0.01361293,0.0002302574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742192,0.02224964,0.000008719929,0.001988237,0.0002377726,0.0003792837,0.0001762095,0.0000376339,0.0007033302],"genre_scores_gemma":[0.9935647,0.005205524,0.00004991185,0.0001556153,0.000008345964,0.00006653131,0.00005647222,0.00001947785,0.0008733691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1774937,"threshold_uncertainty_score":0.6962571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352582711751503,"score_gpt":0.2339941921087472,"score_spread":0.1987359209335969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}