{"id":"W1979129343","doi":"10.1016/j.bmcl.2007.06.097","title":"Cyanine dye conjugates as probes for live cell imaging","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Camille and Henry Dreyfus Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation; National Science Foundation","keywords":"Cyanine; Chemistry; Fluorescence; Conjugate; Live cell imaging; Combinatorial chemistry; Absorption (acoustics); Chemical synthesis; Peptide; Photochemistry; Cell; Biochemistry; Optics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002992353,0.0002663273,0.0002007569,0.00002649111,0.00009667301,0.00002582097,0.0003288032,0.0001313549,0.0002014723],"category_scores_gemma":[0.0001218763,0.0002493589,0.0001223338,0.00007029696,0.0001664234,0.000006304564,0.00008449882,0.0001402482,0.00005076703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003842802,"about_ca_system_score_gemma":0.00009006997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003326292,"about_ca_topic_score_gemma":0.000004371353,"domain_scores_codex":[0.9985076,0.00001062056,0.0003127058,0.0004975121,0.0001854401,0.0004861125],"domain_scores_gemma":[0.9992186,0.00003495586,0.0001286549,0.0003247722,0.000120227,0.0001727858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00016932,0.00004516313,0.001519827,0.00008716994,0.00004189224,0.00003111795,0.00009360546,8.260478e-7,0.9817211,0.000001489634,0.01570973,0.0005787816],"study_design_scores_gemma":[0.0007939684,0.0001218906,0.0003571186,0.00005044167,0.00005308456,0.0001006549,0.0005759193,0.00001026796,0.9833472,0.00001285533,0.01428166,0.0002948818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992385,0.001395652,0.002665323,0.001893278,0.0002095903,0.0002253454,0.0000182264,0.00003150448,0.001176054],"genre_scores_gemma":[0.9929439,0.0000892246,0.0003624937,0.004130509,0.001285812,0.00001842968,0.0002347044,0.00004071672,0.0008941789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302829,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004991926715855919,"score_gpt":0.2339613329717584,"score_spread":0.2289694062559025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}