{"id":"W1979154472","doi":"10.1158/1535-7163.targ-09-c92","title":"Abstract C92: DNA methylating combi-molecule ZRS1 induces p53 and blocks the epidermal growth factor (EGFR)-activated pathways in EGFR-expressing human tumor cells: Relationship to O6-methylguanine DNA methyltransferase (MGMT) status","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Methyltransferase; Cancer research; Biology; DNA methyltransferase; DNA damage; Molecular biology; Chemistry; Biochemistry; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009576969,0.0002820841,0.0002419323,0.0001977088,0.0001050782,0.000143431,0.0001903369,0.0002453217,0.002868179],"category_scores_gemma":[0.0001051311,0.00009466171,0.0001967082,0.0001542595,0.0001706435,0.00009761128,0.00008655452,0.0004056699,0.0003847213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243992,"about_ca_system_score_gemma":0.0001731801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009977348,"about_ca_topic_score_gemma":0.001237402,"domain_scores_codex":[0.9999152,0.00001143689,0.000007754363,0.00001510689,0.00002627449,0.00002427065],"domain_scores_gemma":[0.9999349,0.00001212607,0.00001460992,0.00001106197,0.00001012414,0.00001708381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002636486,0.00007675962,0.0001517552,0.00002945259,0.00000917447,0.00002493375,0.000009089055,0.00009253267,0.997669,0.00007643682,0.0001123953,0.001484775],"study_design_scores_gemma":[0.00004974676,0.001314365,0.001870464,0.000002209933,0.00001576708,0.0001027613,0.00001133952,0.000473076,0.995046,0.00001124889,0.001100979,0.000002096339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972799,0.0006204442,0.0005489078,0.00008136346,0.00001949658,0.00002996142,0.0003909275,0.00005528182,0.0009738182],"genre_scores_gemma":[0.9962797,0.0003529451,0.0006690774,0.00002927434,0.000007531828,0.0000251883,0.0007645653,0.00001097054,0.00186085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002868179,"threshold_uncertainty_score":0.009594977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03847306299729982,"score_gpt":0.3026971667372321,"score_spread":0.2642241037399323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}