{"id":"W1979174109","doi":"10.1056/nejmoa0807650","title":"Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection","year":2009,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Hepatitis C virus research","field":"Medicine","cited_by":1023,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Valeant Pharmaceuticals International; Gilead Sciences; Vertex Pharmaceuticals; Merz Pharmaceuticals; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Telaprevir; Ribavirin; Medicine; Virology; Boceprevir; Hepatitis C virus; Chronic hepatitis; Genotype; Pegylated interferon; Hepacivirus; Peginterferon alfa-2a; Protease inhibitor (pharmacology); Internal medicine; Gastroenterology; Virus; Viral load; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003527075,0.0004499099,0.000583286,0.0002069341,0.0003417139,0.0001710919,0.0002411592,0.0004540332,0.007424791],"category_scores_gemma":[0.0006012305,0.0001107918,0.0003161206,0.0001980178,0.0002304472,0.0001621038,0.000227364,0.0004936511,0.001167563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617762,"about_ca_system_score_gemma":0.0004229769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178159,"about_ca_topic_score_gemma":0.0007285262,"domain_scores_codex":[0.9997426,0.000118618,0.00002281759,0.00003520243,0.00002818583,0.00005263501],"domain_scores_gemma":[0.9997643,0.00004772617,0.00005472203,0.00001154108,0.0000122036,0.0001096526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2825731,0.007628647,0.05448976,0.002132653,0.0009186061,0.002013632,0.000193695,0.00110044,0.02620381,0.0005077528,0.008286941,0.6139509],"study_design_scores_gemma":[0.2445979,0.3097087,0.3390958,0.0007201594,0.001276346,0.01455813,0.0002300854,0.002354016,0.008474089,0.0008944132,0.07799546,0.00009489746],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791768,0.01086775,0.0006806582,0.001011027,0.0002183783,0.00112268,0.0005303216,0.00007513696,0.006317257],"genre_scores_gemma":[0.9858106,0.004515569,0.001422854,0.001003284,0.0004477518,0.001147642,0.0008009913,0.000007973189,0.004843442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007424791,"threshold_uncertainty_score":0.02483845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431857570678463,"score_gpt":0.3676181674281011,"score_spread":0.3244324103602547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}