{"id":"W1979181212","doi":"10.1016/j.str.2005.07.001","title":"Allostery Trumps Antibiotic Resistance","year":2005,"lang":"en","type":"letter","venue":"Structure","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Ankyrin repeat; Kinase; Biology; Enzyme; Signal transduction; Biochemistry; Transferase; Scaffold protein; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007760899,0.0003683034,0.000647755,0.0002434154,0.001001499,0.001304419,0.0007609316,0.0070141,0.003145187],"category_scores_gemma":[0.003031773,0.0002413211,0.0003089672,0.0002099439,0.002926285,0.001398562,0.0009487211,0.006813979,0.001713014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001274519,"about_ca_system_score_gemma":0.0004756262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003183863,"about_ca_topic_score_gemma":0.000635896,"domain_scores_codex":[0.9996331,0.00008902764,0.00002787803,0.00006334812,0.0001166412,0.00007001006],"domain_scores_gemma":[0.9989263,0.000565177,0.00009354333,0.0001871887,0.00009132753,0.00013636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008708746,0.0001595582,0.002064267,0.0003078151,0.00007747835,0.01728613,0.0004072725,0.0009526688,0.03896656,0.2124675,0.5995132,0.1269267],"study_design_scores_gemma":[0.0002572802,0.0003038054,0.001335327,0.00006931692,0.00004269124,0.008963718,0.0002389871,0.003296334,0.02694555,0.1184881,0.840011,0.0000478048],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04282894,0.01603092,0.01381693,0.8139929,0.05136321,0.00004947527,0.0001318564,0.0006400995,0.06114557],"genre_scores_gemma":[0.420492,0.008543834,0.007313582,0.4627086,0.03354728,0.0001038193,0.0001150987,0.0001291728,0.06704655],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0070141,"threshold_uncertainty_score":0.01052171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279266111710122,"score_gpt":0.2080138360793235,"score_spread":0.2007345699676134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}