{"id":"W1979181212","doi":"10.1016/j.str.2005.07.001","title":"Allostery Trumps Antibiotic Resistance","year":2005,"lang":"en","type":"letter","venue":"Structure","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Ankyrin repeat; Kinase; Biology; Enzyme; Signal transduction; Biochemistry; Transferase; Scaffold protein; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008756087,0.0005500559,0.0005448895,0.0001451124,0.0001911705,0.0001945553,0.0006040703,0.00146316,0.004773822],"category_scores_gemma":[0.00004016544,0.0004479535,0.0001657391,0.0001741016,0.0001640007,0.0002092577,0.00008971312,0.001706181,0.00034988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196886,"about_ca_system_score_gemma":0.00009474932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206388,"about_ca_topic_score_gemma":0.0001561677,"domain_scores_codex":[0.9973298,0.0001196634,0.0004084361,0.0008630125,0.0006167378,0.0006623544],"domain_scores_gemma":[0.9985619,0.0000598323,0.0003082865,0.0009148291,0.0000895249,0.00006561972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002113231,0.000001686962,0.00001480201,0.0002033358,0.00001692468,0.0001363642,0.00006972343,0.000005566882,0.05033702,0.0000593827,0.9487498,0.0003842575],"study_design_scores_gemma":[0.0002070213,0.00002741437,0.0002628058,0.0001106571,0.0000766524,0.00007186258,0.000007521758,9.84955e-7,0.03189318,0.001747603,0.9650633,0.0005309389],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04845693,0.004475617,0.000146548,0.8594083,0.02455155,0.001226514,0.00309127,0.001111655,0.05753167],"genre_scores_gemma":[0.05883074,0.00004624904,0.004175784,0.8504654,0.04040032,0.000005541542,0.00110094,0.0002007462,0.04477431],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01844384,"threshold_uncertainty_score":0.9998332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279266111710122,"score_gpt":0.2080138360793235,"score_spread":0.2007345699676134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}