{"id":"W1979248546","doi":"10.1371/journal.pone.0033984","title":"Paradoxical Effects of Rapamycin on Experimental House Dust Mite-Induced Asthma","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Christie (Canada)","funders":"NHLBI Division of Intramural Research; National Cancer Institute; National Institutes of Health; Tuberous Sclerosis Alliance; LAM Foundation; National Heart, Lung, and Blood Institute","keywords":"Sirolimus; PI3K/AKT/mTOR pathway; Mechanistic target of rapamycin; mTORC1; Ribosomal protein s6; Inflammation; Immunology; Medicine; House dust mite; Pharmacology; Biology; Internal medicine; P70-S6 Kinase 1; Signal transduction; Allergy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190505,0.000453635,0.0008755953,0.0003338483,0.0002130679,0.0002372961,0.0002388795,0.0004783342,0.0006713505],"category_scores_gemma":[0.0002453639,0.0001580383,0.0003974813,0.000155216,0.0004615663,0.0002981019,0.0002315263,0.001552857,0.0001600436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448079,"about_ca_system_score_gemma":0.0002061351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001879409,"about_ca_topic_score_gemma":0.0005548848,"domain_scores_codex":[0.999639,0.0001158493,0.00003245021,0.00006267458,0.00008582258,0.00006424786],"domain_scores_gemma":[0.9997653,0.00005361374,0.00006281816,0.00003187838,0.00001720445,0.00006925216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003102255,0.0007511016,0.0007382491,0.0001335625,0.00002353162,0.0001980183,0.00003546516,0.0001525103,0.9890947,0.00008790278,0.0001125948,0.005570017],"study_design_scores_gemma":[0.0002502926,0.01888517,0.02353057,0.00001766373,0.00009079628,0.0007761601,0.00007480174,0.00157716,0.9528983,0.000106402,0.001771459,0.00002125342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959816,0.002323835,0.0006955608,0.0001222928,0.00009559069,0.00005588335,0.0001402366,0.0000817749,0.0005032524],"genre_scores_gemma":[0.997,0.0009336602,0.001051816,0.0001093107,0.00006120901,0.00007521566,0.0001948281,0.0000129883,0.0005609061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008755953,"threshold_uncertainty_score":0.002245903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713560803389337,"score_gpt":0.2256827162436958,"score_spread":0.1985471082098025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}