{"id":"W1979300200","doi":"10.1016/s0304-3835(00)00368-2","title":"Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics","year":2000,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Oxidative stress; Glutathione; Chemistry; Hydrogen peroxide; Biochemistry; Phenols; Glutathione S-transferase; Oxidative phosphorylation; Antioxidant; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230922,0.0001829616,0.0002328025,0.00002026897,0.0001206535,0.00001579968,0.000227105,0.00006648168,0.00003366356],"category_scores_gemma":[0.000007794553,0.0001119673,0.00009658711,0.00009142342,0.0003772261,0.00001499146,0.00003080965,0.0001050153,1.995554e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001465083,"about_ca_system_score_gemma":0.00004497226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007088499,"about_ca_topic_score_gemma":0.0005865381,"domain_scores_codex":[0.9988916,0.000217643,0.000249623,0.0002795472,0.0001963203,0.0001652843],"domain_scores_gemma":[0.9993694,0.00005394157,0.000161509,0.000313151,0.00005169029,0.00005031026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007720909,0.00003656315,0.0002845493,0.00007132367,0.0002305553,7.503187e-7,0.001422386,0.001100344,0.99436,0.00003347365,0.00009095424,0.001597047],"study_design_scores_gemma":[0.00105485,0.00004604249,0.002931451,0.000103598,0.0002449801,0.000001523047,0.0005086567,0.00003770148,0.9947779,0.00003865062,0.0001245016,0.0001302127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986609,0.006656372,0.00129487,0.004110148,0.0000358233,0.0005964808,0.000685134,0.000003146939,0.000008969002],"genre_scores_gemma":[0.9934044,0.005234255,0.0001009495,0.001020955,0.00003600227,0.00006775931,0.00004635037,0.00001864249,0.00007066142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006795369,"threshold_uncertainty_score":0.4565896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008196187839696003,"score_gpt":0.2271985401992073,"score_spread":0.2190023523595113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}