{"id":"W1979308615","doi":"10.1038/sj.onc.1204890","title":"A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Cancer Care Ontario; U.S. Department of Defense","keywords":"CREB; Biology; Promoter; Transcriptional regulation; Molecular biology; Transcription factor; Response element; Binding site; Cancer research; Gene expression; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023873,0.0005848695,0.0005526243,0.0005061346,0.0005821316,0.0004410179,0.0008807824,0.0008351483,0.005050777],"category_scores_gemma":[0.0004835568,0.0004893654,0.0005211378,0.0002434201,0.000970117,0.0003649156,0.0006670967,0.00197974,0.003037981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009306103,"about_ca_system_score_gemma":0.0007792112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001773375,"about_ca_topic_score_gemma":0.003516454,"domain_scores_codex":[0.999663,0.00003177047,0.00001822425,0.0001027017,0.00009183575,0.00009245783],"domain_scores_gemma":[0.9995684,0.0001297743,0.00006089935,0.00007465829,0.00003893676,0.0001272821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002085006,0.00005298045,0.0002207904,0.0001053974,0.000006275623,0.0001650271,0.00003027505,0.0001138712,0.9939759,0.00114333,0.0004216699,0.003555854],"study_design_scores_gemma":[0.00003963452,0.00004860497,0.0009880756,0.00002221089,0.00001121281,0.0003185733,0.0000290537,0.0005340947,0.9915813,0.0002187421,0.006194673,0.00001387674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8983406,0.003150249,0.07274184,0.001322472,0.0008446563,0.0003713921,0.003406323,0.003291838,0.01653071],"genre_scores_gemma":[0.953235,0.0006192377,0.02978184,0.0002939313,0.00005099515,0.0001610497,0.001592648,0.0003285702,0.01393668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005050777,"threshold_uncertainty_score":0.01689655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056653558348932,"score_gpt":0.2973848745134886,"score_spread":0.2868183389299993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}