{"id":"W1979330744","doi":"10.1038/cdd.2011.22","title":"Structural and mechanistic basis of Parl activity and regulation","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Rhomboid; Transmembrane domain; Cell biology; Protease; Biology; Chemistry; Biochemistry; Proteases; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097653,0.0001925717,0.0001695037,0.0002100661,0.0003490858,0.00101271,0.0005211865,0.0004395776,0.00177027],"category_scores_gemma":[0.0003132169,0.0002110357,0.0002315067,0.0001255476,0.0005914278,0.0007080538,0.0003860277,0.0006656532,0.001244548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477217,"about_ca_system_score_gemma":0.0001491145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001978625,"about_ca_topic_score_gemma":0.0001855407,"domain_scores_codex":[0.9997923,0.00003622002,0.00001304795,0.0000679737,0.00004110152,0.00004942801],"domain_scores_gemma":[0.9997835,0.00004380076,0.00005646648,0.00003915002,0.00002951585,0.00004759972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001763008,0.00002249973,0.000507637,0.00003349612,0.000005187651,0.000155699,0.00004871106,0.0001785379,0.9877825,0.007702819,0.0002081767,0.003178366],"study_design_scores_gemma":[0.00004225511,0.0001185263,0.01007977,0.000007768493,0.00001296769,0.001331225,0.00009676933,0.005432486,0.9655392,0.003340137,0.01398231,0.00001666866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539566,0.004649354,0.026632,0.002292704,0.000165975,0.00003985243,0.0008230527,0.0004727949,0.01096766],"genre_scores_gemma":[0.9939056,0.00048869,0.003094906,0.0001572264,0.00005144446,0.00002032373,0.0003540156,0.0000276448,0.001900199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177027,"threshold_uncertainty_score":0.005922079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207726405283046,"score_gpt":0.2064797583650877,"score_spread":0.1944024943122572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}