{"id":"W1979330744","doi":"10.1038/cdd.2011.22","title":"Structural and mechanistic basis of Parl activity and regulation","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Rhomboid; Transmembrane domain; Cell biology; Protease; Biology; Chemistry; Biochemistry; Proteases; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001925034,0.00006590849,0.00006704719,0.00001699837,0.00003924025,0.000009295537,0.00001506315,0.00004958913,0.00001269487],"category_scores_gemma":[0.00001170618,0.00005658721,0.00001414073,0.00001124063,0.00002689223,0.000004912839,0.00002969378,0.00001620128,1.057323e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001291153,"about_ca_system_score_gemma":0.000006173968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003439945,"about_ca_topic_score_gemma":0.000008186437,"domain_scores_codex":[0.9996756,0.00001871261,0.00006513677,0.0001412567,0.00003786141,0.00006140989],"domain_scores_gemma":[0.9997946,0.000004938005,0.00005245521,0.00007130719,0.00002021871,0.00005649306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002173997,0.00003906479,0.1621758,0.000153829,0.00001957192,5.128477e-7,0.0001086517,9.591258e-7,0.8286214,0.001780863,0.00001165644,0.006870311],"study_design_scores_gemma":[0.000344599,0.0000938712,0.6498151,0.000005050077,0.00003883678,0.000001625623,0.00001623855,0.001177209,0.3473822,0.001059208,0.00000404479,0.00006190454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975649,0.0003453659,0.001556483,0.000003081449,0.00002694852,0.00006516781,0.00001251677,0.000002900346,0.0004226177],"genre_scores_gemma":[0.999442,0.0002332063,0.0001959813,0.000006279612,0.00001526717,0.000003125667,0.0000425014,0.000004050818,0.00005751748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4876393,"threshold_uncertainty_score":0.230756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207726405283046,"score_gpt":0.2064797583650877,"score_spread":0.1944024943122572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}