{"id":"W1979338861","doi":"10.1371/journal.pbio.1001869","title":"Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web","year":2014,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alexander von Humboldt-Stiftung; University of British Columbia; Michael Smith Health Research BC; Bundesministerium für Bildung und Forschung; National Institutes of Health","keywords":"Proteases; Protease; Biology; Biochemistry; Cell biology; Computational biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004416965,0.0001653402,0.0001898647,0.0000494825,0.0001736532,0.00001662542,0.0002126921,0.0002205673,0.00004098404],"category_scores_gemma":[0.000208396,0.0001175201,0.00008547772,0.0001277299,0.0000904363,0.000005392092,0.00007921164,0.0001503281,0.00001798314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001283546,"about_ca_system_score_gemma":0.00005380328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003583545,"about_ca_topic_score_gemma":0.00003302156,"domain_scores_codex":[0.9983985,0.0005550123,0.000257999,0.0003871401,0.0001076581,0.0002936857],"domain_scores_gemma":[0.9993565,0.00003993272,0.0001233641,0.0003611418,0.00006928412,0.00004979289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004622516,0.00007359209,0.02806258,0.00001342444,0.00004287019,8.441874e-7,0.00001618125,0.00003798189,0.9679065,0.001052566,0.002400824,0.0003464317],"study_design_scores_gemma":[0.001502232,0.001972115,0.05377648,0.00007797664,0.0001291922,0.00001589267,0.00006854909,0.0002762848,0.8955265,0.03212782,0.0139506,0.0005763462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961157,0.0002136192,0.001456783,0.0004535292,0.00006357731,0.0008006458,0.00002357685,0.00001922741,0.0008533314],"genre_scores_gemma":[0.9956428,0.000004803956,0.0002709048,0.0006433597,0.00223617,0.0003296915,0.00073752,0.00001428636,0.0001205034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07237996,"threshold_uncertainty_score":0.4792329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05788077669028154,"score_gpt":0.2989041553144593,"score_spread":0.2410233786241777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}