{"id":"W1979345759","doi":"10.1021/ol8009978","title":"Diastereoselective Pictet−Spengler Approach for the Synthesis of Pyrrolo[3,2-<i>e</i>][1,4]diazepin-2-one Peptide Turn Mimics","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Dihedral angle; Turn (biochemistry); Peptide; Residue (chemistry); Ring (chemistry); Stereochemistry; Pictet–Spengler reaction; Combinatorial chemistry; Molecule; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618766,0.0001946772,0.0002960857,0.00003068412,0.000142389,0.00001223804,0.0003615901,0.000117253,0.00004855197],"category_scores_gemma":[0.0003320004,0.0001448965,0.0002936897,0.0001661635,0.0001941421,0.000004757537,0.00008771374,0.0001038755,0.000004884975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002638339,"about_ca_system_score_gemma":0.00003870457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002411245,"about_ca_topic_score_gemma":0.000009318386,"domain_scores_codex":[0.9988253,0.00005374831,0.0002741434,0.000380821,0.0001630946,0.0003029564],"domain_scores_gemma":[0.9990668,0.0001886416,0.0001532677,0.0004487102,0.00007653491,0.00006608256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005633965,0.0001112731,0.0008725649,0.00002327696,0.0003457704,5.81988e-7,0.00009718716,0.00002435958,0.9934697,0.000005621549,0.003990453,0.001002888],"study_design_scores_gemma":[0.0002819156,0.00004269705,0.001694287,0.000007936394,0.0001905057,0.00001209855,0.00008348347,0.0001373446,0.9946057,0.000005581333,0.002751441,0.000186991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804207,0.0003533298,0.01704775,0.001632484,0.00003833748,0.0002576039,0.00003455411,0.00001255036,0.0002026502],"genre_scores_gemma":[0.9953679,0.0003224194,0.002266321,0.00150803,0.000296858,0.00006372501,0.00003811328,0.00004252243,0.00009413601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01494714,"threshold_uncertainty_score":0.5908707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210132022657772,"score_gpt":0.1967283493890986,"score_spread":0.1846270291625209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}