{"id":"W1979364783","doi":"10.1158/1078-0432.ccr-14-3026","title":"Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Howard Hughes Medical Institute","keywords":"Osteosarcoma; PI3K/AKT/mTOR pathway; Druggability; Cancer research; Biology; Computational biology; Medicine; Bioinformatics; Signal transduction; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000380189,0.0006535685,0.0007606953,0.0006549088,0.0002773114,0.0005281901,0.0003690617,0.0003262171,0.001446245],"category_scores_gemma":[0.000272639,0.0002252874,0.0005170763,0.000425301,0.0004406438,0.0002093215,0.0004047006,0.0004995286,0.0003313901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004459991,"about_ca_system_score_gemma":0.0008635301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004604542,"about_ca_topic_score_gemma":0.002422021,"domain_scores_codex":[0.9997106,0.00003873949,0.00002962187,0.00006158332,0.0001153425,0.00004400272],"domain_scores_gemma":[0.9998282,0.00003488038,0.00005733245,0.00002023011,0.00003262558,0.00002659416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001487948,0.0001154542,0.0007855181,0.0001652462,0.00002480328,0.00009776396,0.00001027314,0.0003248473,0.9906669,0.0001244175,0.0001074739,0.007428368],"study_design_scores_gemma":[0.00007800566,0.002388383,0.006094329,0.00002600351,0.0001917688,0.0008456367,0.00004061518,0.0011275,0.98476,0.0001064042,0.004326785,0.000014595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735274,0.00943601,0.01013949,0.0004411909,0.00006981906,0.0004450884,0.001344205,0.0003991857,0.004197545],"genre_scores_gemma":[0.9823699,0.006457984,0.00774708,0.0001967497,0.00001941759,0.0001584053,0.001333284,0.00003899013,0.001678146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446245,"threshold_uncertainty_score":0.004838169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2775449589262783,"score_gpt":0.5097353448381213,"score_spread":0.232190385911843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}