{"id":"W1979374480","doi":"10.1097/01.fpc.0000174786.85238.63","title":"No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPARγ act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma","year":2005,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bishop's University","funders":"","keywords":"Odds ratio; Colorectal cancer; Peroxisome proliferator-activated receptor; CYP2C9; Cytochrome P450; Internal medicine; Confidence interval; Case-control study; Medicine; CYP2C8; Pharmacology; Gastroenterology; Oncology; Endocrinology; Receptor; Cancer; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002406541,0.0003276508,0.0005444117,0.0009389861,0.0003087573,0.0006423569,0.000668631,0.0009527731,0.00391457],"category_scores_gemma":[0.009977605,0.0003015349,0.0008056639,0.001118402,0.001202526,0.0002649727,0.0003076999,0.0005370977,0.00028215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458022,"about_ca_system_score_gemma":0.0003968879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002186475,"about_ca_topic_score_gemma":0.001882373,"domain_scores_codex":[0.998526,0.000470355,0.0001438344,0.0004229597,0.0003531163,0.00008368112],"domain_scores_gemma":[0.9874513,0.00671387,0.002953218,0.001403465,0.0009445234,0.0005336954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002872113,0.00008319334,0.9793229,0.0003102242,0.001898083,0.0005631965,0.0001663768,0.00008503701,0.005916676,0.0001727497,0.0001343632,0.008475053],"study_design_scores_gemma":[0.0001354671,0.0008272909,0.9923182,0.0000656031,0.001527935,0.002172928,0.0001043546,0.0001956706,0.00156574,0.00014987,0.0009276634,0.000009360855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913386,0.006031831,0.0006116584,0.0003388145,0.00004134208,0.00001411193,0.0001801719,0.00001597236,0.001427552],"genre_scores_gemma":[0.9982197,0.0009955518,0.0003225367,0.0001052694,0.00004696146,0.000004002851,0.0001286194,0.000003917448,0.000173556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00391457,"threshold_uncertainty_score":0.0130955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808367809710427,"score_gpt":0.2575863891985746,"score_spread":0.2395027111014703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}