{"id":"W1979374480","doi":"10.1097/01.fpc.0000174786.85238.63","title":"No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPARγ act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma","year":2005,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bishop's University","funders":"","keywords":"Odds ratio; Colorectal cancer; Peroxisome proliferator-activated receptor; CYP2C9; Cytochrome P450; Internal medicine; Confidence interval; Case-control study; Medicine; CYP2C8; Pharmacology; Gastroenterology; Oncology; Endocrinology; Receptor; Cancer; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008918654,0.0002296725,0.0004514121,0.00009145611,0.00007449378,0.000009356715,0.0001532094,0.0001013563,0.00001258162],"category_scores_gemma":[0.0003697082,0.0001366809,0.0001223737,0.0001404332,0.0003695894,0.00004848789,0.0001038913,0.0002878941,0.000001812155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006355401,"about_ca_system_score_gemma":0.0001071398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306438,"about_ca_topic_score_gemma":0.00002041625,"domain_scores_codex":[0.9985462,0.0003561653,0.0003369552,0.0002550572,0.0002745081,0.0002310617],"domain_scores_gemma":[0.9983576,0.0007474867,0.0003966811,0.0003062613,0.00008521527,0.0001067328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004048453,0.00009166401,0.3774973,0.0002889763,0.0001863033,0.000009813241,0.001629552,0.000560732,0.6088467,0.00003649307,0.00004916744,0.00675483],"study_design_scores_gemma":[0.001702428,0.001130713,0.1694174,0.0001917957,0.0002882837,0.00001889444,0.00002575331,0.004457882,0.8224599,0.00002407959,0.0001696528,0.0001131925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956384,0.002285592,0.000007684602,0.0001325998,0.0001215705,0.001700136,0.00004082115,0.000004463779,0.00006869372],"genre_scores_gemma":[0.9977784,0.001867755,0.0000834667,0.00008969144,0.00008045053,0.00004426404,0.000001227201,0.00002572123,0.00002900425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2136132,"threshold_uncertainty_score":0.5573685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808367809710427,"score_gpt":0.2575863891985746,"score_spread":0.2395027111014703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}