{"id":"W1979378213","doi":"10.1158/0008-5472.sabcs13-pd5-7","title":"Abstract PD5-7: Phase Ib study of LCL161, an oral antagonist of inhibitor of apoptosis proteins, in combination with weekly paclitaxel in patients with advanced solid tumors: Safety and efficacy results, including breast cancer cohort","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Neutropenia; Febrile neutropenia; Pharmacokinetics; Paclitaxel; Ovarian cancer; Pharmacology; Pharmacodynamics; Cancer; Internal medicine; Adverse effect; Chemotherapy; Breast cancer; Combination therapy; Tolerability; Oncology; Inhibitor of apoptosis; Gastroenterology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007608036,0.0008158269,0.001082485,0.000357846,0.0003546782,0.0006611493,0.0005832987,0.0005367647,0.002107097],"category_scores_gemma":[0.0003781226,0.0003336657,0.0005935438,0.0003104119,0.0005512436,0.0004016868,0.0002659208,0.001921976,0.0005669179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008847704,"about_ca_system_score_gemma":0.001215461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008862683,"about_ca_topic_score_gemma":0.001751391,"domain_scores_codex":[0.9997504,0.00009793686,0.00001871178,0.00004216496,0.00004039687,0.00005031707],"domain_scores_gemma":[0.9997233,0.00003254298,0.00005179056,0.00002369067,0.00002016324,0.0001484527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4810853,0.08057039,0.02849701,0.0009444621,0.001702358,0.0005411099,0.0003693542,0.004156373,0.1895656,0.0003495121,0.005559539,0.2066589],"study_design_scores_gemma":[0.2644601,0.6457971,0.03769666,0.0000542973,0.0009287007,0.0007546356,0.00009002932,0.003515364,0.04065466,0.0001764865,0.005836436,0.00003553583],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962602,0.001225372,0.0003250541,0.0001640252,0.00002473312,0.0005752418,0.0004336575,0.00005841927,0.000933475],"genre_scores_gemma":[0.9949698,0.0007735507,0.0008959134,0.0001999038,0.00004868365,0.0005191314,0.001223562,0.00001324511,0.001356243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002107097,"threshold_uncertainty_score":0.007048905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146484204743586,"score_gpt":0.3480915310082615,"score_spread":0.3266266889608256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}