{"id":"W1979386452","doi":"10.1016/j.bmc.2006.07.055","title":"In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"NeurAxon (Canada); Université Laval; Hôpital Saint-François d'Assise","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; CYP3A4; P-glycoprotein; Cytotoxicity; Pharmacology; In vitro; Context (archaeology); IC50; Enzyme; Biochemistry; Multiple drug resistance; Stereochemistry; Cytochrome P450; Antibiotics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560633,0.0003267366,0.0003350242,0.0001424204,0.0001341938,0.0001654536,0.0001835931,0.0001852697,0.001633519],"category_scores_gemma":[0.0002838465,0.0001440051,0.000139268,0.0001653605,0.0001411037,0.0001789829,0.0001197898,0.000424635,0.0002669379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400489,"about_ca_system_score_gemma":0.0001163754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005569626,"about_ca_topic_score_gemma":0.0006670872,"domain_scores_codex":[0.999866,0.00004915777,0.00001231163,0.0000180252,0.00002649401,0.00002807858],"domain_scores_gemma":[0.9998587,0.00006286226,0.00002689387,0.00001379832,0.0000147164,0.00002299642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001517846,0.0003203125,0.0004033174,0.00009129296,0.00002149329,0.0001310328,0.00004268088,0.0005083649,0.990071,0.0001188974,0.0001820356,0.006591782],"study_design_scores_gemma":[0.0001703163,0.004516198,0.002372526,0.000007897487,0.00004947202,0.0003468635,0.00001424919,0.001302225,0.9894694,0.0000239499,0.001720304,0.000006642611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937778,0.003519233,0.0008385274,0.00005780688,0.00003267824,0.00002412467,0.0002210548,0.00005078765,0.001477967],"genre_scores_gemma":[0.9957321,0.001637068,0.0007810523,0.0000202231,0.00002713657,0.00002064808,0.0005651884,0.000008020133,0.001208633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633519,"threshold_uncertainty_score":0.005464673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253972844594935,"score_gpt":0.2392781625976245,"score_spread":0.2267384341516752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}