{"id":"W1979401973","doi":"10.1016/j.tox.2009.10.025","title":"Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: Its regulation by aryl hydrocarbon receptor agonists","year":2009,"lang":"en","type":"article","venue":"Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Aryl hydrocarbon receptor; Messenger RNA; CYP1B1; Internal medicine; Gene expression; Cytochrome P450; Endocrinology; Molecular biology; Biochemistry; Biology; Gene; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628593,0.0004696831,0.0004227363,0.0007899164,0.0002690835,0.0002967536,0.0001759221,0.000266091,0.001206468],"category_scores_gemma":[0.0002914645,0.0003027219,0.0003709861,0.000280517,0.0003538191,0.000246897,0.0001252115,0.0007592783,0.000310556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003107716,"about_ca_system_score_gemma":0.000363524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00168443,"about_ca_topic_score_gemma":0.002487948,"domain_scores_codex":[0.9998666,0.00001993267,0.000008475836,0.00003396732,0.00003622388,0.00003478435],"domain_scores_gemma":[0.9995634,0.00004964475,0.0001144309,0.00004440681,0.00006893031,0.0001593342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001234529,0.00009876931,0.00445067,0.00002902285,0.00002863735,0.0001058352,0.00003711045,0.0001011858,0.9900104,0.0001605616,0.00007645101,0.003666825],"study_design_scores_gemma":[0.00004601623,0.001154602,0.0528946,0.000007117165,0.0001144024,0.0005785376,0.0001000632,0.001100522,0.9420512,0.0001914487,0.001743803,0.00001759846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994948,0.0006778354,0.00326185,0.000141713,0.00002505413,0.00001469874,0.0005465214,0.00005079923,0.0003334678],"genre_scores_gemma":[0.9930072,0.0006345836,0.002044275,0.0000680068,0.00002502754,0.00003680421,0.0009902552,0.00004814588,0.003145663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168443,"threshold_uncertainty_score":0.004036009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05629017069368933,"score_gpt":0.3788697829720624,"score_spread":0.3225796122783731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}