{"id":"W1979401973","doi":"10.1016/j.tox.2009.10.025","title":"Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: Its regulation by aryl hydrocarbon receptor agonists","year":2009,"lang":"en","type":"article","venue":"Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Aryl hydrocarbon receptor; Messenger RNA; CYP1B1; Internal medicine; Gene expression; Cytochrome P450; Endocrinology; Molecular biology; Biochemistry; Biology; Gene; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006002691,0.0003311792,0.0005980951,0.0003113101,0.00009674754,0.00001453376,0.0003504202,0.000662325,0.001940394],"category_scores_gemma":[0.00008629241,0.000363679,0.0001028727,0.0005503115,0.0001116358,0.0001834161,0.00005999197,0.000587874,0.0001348936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113906,"about_ca_system_score_gemma":0.000202958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001170131,"about_ca_topic_score_gemma":0.0000103344,"domain_scores_codex":[0.9974729,0.0004073551,0.0008120037,0.0004943995,0.0001993218,0.0006139989],"domain_scores_gemma":[0.9988192,0.0001256137,0.000411389,0.0002455792,0.00009099924,0.0003072231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005250608,0.0005735733,0.0002733908,0.00002061221,0.00004890802,0.000009964547,0.0005826974,0.0002034539,0.9686878,0.000927009,0.004161584,0.02398589],"study_design_scores_gemma":[0.002459465,0.0003186097,0.01872023,0.00001453089,0.00007416289,0.00001259085,0.0000105663,0.002188694,0.8492095,0.000669607,0.1260139,0.0003082133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918195,0.001313139,0.0002180621,0.002580958,0.0008248529,0.0007610291,0.0001119119,0.00008118839,0.002289342],"genre_scores_gemma":[0.9922886,0.00112657,0.0001403394,0.00352692,0.0004369272,0.00003921318,0.0003239192,0.00003125311,0.00208623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1218523,"threshold_uncertainty_score":0.9998815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05629017069368933,"score_gpt":0.3788697829720624,"score_spread":0.3225796122783731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}