{"id":"W1979408593","doi":"10.1021/ja211524d","title":"Scaffold Tailoring by a Newly Detected Pictet–Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Zhejiang University; National Natural Science Foundation of China; University of Reading; Fonds der Chemischen Industrie","keywords":"Chemistry; Indole test; Enzyme; Scaffold; Biosynthesis; ATP synthase; Stereochemistry; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273619,0.0002194232,0.0001553966,0.00008982784,0.00006749582,0.0002266508,0.000168698,0.0002445956,0.0006499147],"category_scores_gemma":[0.0001369964,0.00007949807,0.0001541272,0.00008024403,0.0001755257,0.0001855133,0.0001748412,0.0003125354,0.0002172169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001497386,"about_ca_system_score_gemma":0.0001208135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001332164,"about_ca_topic_score_gemma":0.0002137045,"domain_scores_codex":[0.9999541,0.000008100117,0.000003780829,0.00001230119,0.00001156846,0.00001014393],"domain_scores_gemma":[0.9999503,0.00000968582,0.00001401884,0.000007190905,0.000004221341,0.0000146479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005563189,0.00001361274,0.0001575823,0.00002995982,0.000003269443,0.0001008721,0.00001752364,0.0002116731,0.9966211,0.0002475026,0.00003348535,0.002507697],"study_design_scores_gemma":[0.000009355506,0.0002239509,0.0007728204,0.000001912921,0.000005516365,0.0003712407,0.000008796039,0.0008270154,0.9958313,0.00005513912,0.001886596,0.000006476904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893055,0.000813026,0.007571459,0.00007660507,0.00001531765,0.00002298777,0.00012512,0.00009613434,0.001973752],"genre_scores_gemma":[0.9942989,0.0003361851,0.004203719,0.00002483354,0.000003612354,0.000008882784,0.0001841266,0.000009473103,0.000930189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006499147,"threshold_uncertainty_score":0.002174258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531036916463725,"score_gpt":0.2520594546936336,"score_spread":0.2367490855289964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}