{"id":"W1979408593","doi":"10.1021/ja211524d","title":"Scaffold Tailoring by a Newly Detected Pictet–Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Zhejiang University; National Natural Science Foundation of China; University of Reading; Fonds der Chemischen Industrie","keywords":"Chemistry; Indole test; Enzyme; Scaffold; Biosynthesis; ATP synthase; Stereochemistry; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380193,0.0001974536,0.0003442571,0.000007852457,0.0001371848,0.0000224429,0.0008885185,0.0001108617,0.00002553373],"category_scores_gemma":[0.0001203333,0.0001054675,0.0005049038,0.0002867399,0.0002064779,0.000006604665,0.0002701128,0.0004690617,6.744353e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006447892,"about_ca_system_score_gemma":0.00009088303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003883115,"about_ca_topic_score_gemma":0.00001905164,"domain_scores_codex":[0.9987723,0.0001139565,0.0003399951,0.0002005382,0.0003105585,0.0002626931],"domain_scores_gemma":[0.99843,0.0001346307,0.0006485241,0.0005312451,0.0001308352,0.0001248137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000393106,0.0001356562,0.0005019212,0.00000379422,0.0002429742,5.629245e-7,0.0004940323,0.00001212642,0.9863504,0.000005920667,0.003451717,0.00840778],"study_design_scores_gemma":[0.0004518624,0.0003094212,0.001446358,0.00005013205,0.0001112419,0.00001030979,0.0004028862,0.00004314683,0.9901256,0.0001336506,0.006777941,0.0001374808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918724,0.0005659463,0.005041962,0.002047926,0.000180682,0.0001728109,0.00009519202,0.000005151574,0.00001794747],"genre_scores_gemma":[0.9947403,0.0003786386,0.002216775,0.002072742,0.0005360884,0.000007952762,0.000004827261,0.00002647622,0.00001616437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0082703,"threshold_uncertainty_score":0.4300841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531036916463725,"score_gpt":0.2520594546936336,"score_spread":0.2367490855289964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}