{"id":"W1979421565","doi":"10.1038/nm1483","title":"Targeting of CD44 eradicates human acute myeloid leukemic stem cells","year":2006,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":1199,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Stem cell; Myeloid leukemia; CD44; Cancer research; Haematopoiesis; Leukemia; Myeloid; Cancer stem cell; Biology; Immunology; Medicine; Cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068811,0.0001882295,0.0002445702,0.0001841975,0.0001832654,0.0004824129,0.0001323875,0.000216281,0.001259438],"category_scores_gemma":[0.0001012212,0.0001134194,0.0001955193,0.0001287676,0.0001280488,0.000140385,0.0001915964,0.000640896,0.0004420406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795668,"about_ca_system_score_gemma":0.0003036121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006517693,"about_ca_topic_score_gemma":0.001466708,"domain_scores_codex":[0.9998703,0.00001769466,0.000006375639,0.00001612024,0.00003826438,0.00005131231],"domain_scores_gemma":[0.9999547,0.000009881251,0.000007562633,0.00001056408,0.000005143779,0.00001220549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607197,0.000177961,0.0005447721,0.00004249951,0.00001639863,0.00006782301,0.00003526856,0.0003587755,0.9838648,0.0008231162,0.0005504153,0.01335743],"study_design_scores_gemma":[0.00009812476,0.0006126018,0.006000424,0.000006655915,0.00003195805,0.000386472,0.00005929535,0.004867675,0.9760522,0.0002280245,0.01165174,0.000004909117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943224,0.001249444,0.001798576,0.0002809028,0.00004647503,0.00002788963,0.0001249231,0.0001003687,0.002049008],"genre_scores_gemma":[0.9950579,0.0006585092,0.001048339,0.00006412101,0.0000159801,0.00001664184,0.000229007,0.00001532101,0.002894179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259438,"threshold_uncertainty_score":0.004213274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008170756869141975,"score_gpt":0.2668110121194949,"score_spread":0.2586402552503529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}