{"id":"W1979430819","doi":"10.1016/j.nbd.2005.08.007","title":"Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models","year":2005,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Huntingtin; Huntington's disease; Phenotype; Mutant; Excitotoxicity; Huntingtin Protein; Biology; Trinucleotide repeat expansion; Mutation; Genetics; Gene; Internal medicine; Allele; Disease; Medicine; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143259,0.0002968812,0.0004489497,0.0001800347,0.00008228993,0.000009637036,0.0008369573,0.00005859865,0.00006088104],"category_scores_gemma":[0.001657485,0.0002437673,0.0001994248,0.0004364414,0.001073917,0.0002127116,0.0003102532,0.0002189426,0.000007564119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001800796,"about_ca_system_score_gemma":0.0002731602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003578192,"about_ca_topic_score_gemma":0.00001872761,"domain_scores_codex":[0.9969777,0.000744835,0.0008301619,0.000699677,0.0003116756,0.0004359044],"domain_scores_gemma":[0.9976491,0.0005332573,0.0005497093,0.0008709819,0.0001535359,0.0002434705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005756135,0.0007737257,0.0467218,0.0001471383,0.000005927901,0.000001427359,0.0001913507,0.06440402,0.8857288,0.0009892257,0.00001634476,0.0004446547],"study_design_scores_gemma":[0.0005346378,0.0000721255,0.2723407,0.00003924504,0.0000429776,1.159609e-7,0.00001302577,0.001882166,0.724099,0.0008072919,0.00001485659,0.0001539081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978202,0.00005683529,0.00003829392,0.000565947,0.00007872006,0.000568801,0.000760257,0.00003220553,0.00007874829],"genre_scores_gemma":[0.9988183,0.00004617854,0.00007762454,0.0009161085,0.00003072684,0.00003401426,0.000005054827,0.0000305618,0.00004147726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2256189,"threshold_uncertainty_score":0.9940542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02743525935967473,"score_gpt":0.2605684902556133,"score_spread":0.2331332308959386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}