{"id":"W1979457312","doi":"10.1016/j.ddstr.2013.11.001","title":"Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure","year":2012,"lang":"en","type":"review","venue":"Drug Discovery Today Therapeutic Strategies","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Heart and Stroke Foundation of Canada","keywords":"Angiotensin-converting enzyme 2; Heart failure; Angiotensin II; Angiotensin II receptor type 1; Pressure overload; Internal medicine; Receptor; Endocrinology; Renin–angiotensin system; Ventricular remodeling; Medicine; Muscle hypertrophy; Angiotensin-converting enzyme; Myocardial infarction; Angiotensin 1; Fibrosis; Blood pressure; Pharmacology; Cardiac hypertrophy; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058302,0.0009159789,0.001744553,0.001342254,0.0001551933,0.0007167954,0.0006146102,0.0007850013,0.002219474],"category_scores_gemma":[0.0006468759,0.0002517454,0.0005302105,0.001069149,0.0003272534,0.0009293137,0.0003993625,0.001501288,0.0009017289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872621,"about_ca_system_score_gemma":0.000598921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004346467,"about_ca_topic_score_gemma":0.001191884,"domain_scores_codex":[0.999878,0.00002080861,0.0000223759,0.00002258844,0.00004396218,0.00001212478],"domain_scores_gemma":[0.9997372,0.0001639224,0.00003944325,0.000005877293,0.00003599441,0.00001752528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000381302,0.0002081477,0.0002447329,0.02257132,0.0002990757,0.0003491207,0.00002975285,0.0003242246,0.004523022,0.001647845,0.01600888,0.9534125],"study_design_scores_gemma":[0.0005632158,0.0009458206,0.002942609,0.006999483,0.001942987,0.003215692,0.0001083353,0.0005207747,0.004742234,0.003831304,0.974114,0.0000735663],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002196751,0.9989032,0.0001487793,0.0001642043,0.0001216539,0.000004483095,0.00001241536,0.000005685683,0.0004199152],"genre_scores_gemma":[0.001318746,0.9976647,0.0002448841,0.0002299381,0.0001866693,0.000007018412,0.00002026132,0.000001068113,0.0003268182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002219474,"threshold_uncertainty_score":0.007424891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05245593690220392,"score_gpt":0.3157799530829468,"score_spread":0.2633240161807429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}