{"id":"W1979488027","doi":"10.1001/jama.297.21.2360","title":"Founder and Recurrent CDH1 Mutations in Families With Hereditary Diffuse Gastric Cancer","year":2007,"lang":"en","type":"article","venue":"JAMA","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":454,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Memorial University of Newfoundland; Université de Montréal; Queen's University; Children's Hospital of Eastern Ontario; McGill University; University of British Columbia; Health Sciences Centre; BC Cancer Agency","funders":"National Cancer Institute","keywords":"Missense mutation; Haplotype; Medicine; Cancer; Germline mutation; Genetics; CDH1; Mutation; Breast cancer; Internal medicine; Gene; Allele; Biology; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003633799,0.0004688419,0.0003146434,0.001162145,0.0008422249,0.0002813031,0.0002851958,0.0004599526,0.00209867],"category_scores_gemma":[0.002341026,0.0002576905,0.0002025137,0.0008109192,0.0007043788,0.0002223712,0.0004522949,0.0002957478,0.0001249604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006176114,"about_ca_system_score_gemma":0.0003746154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00831055,"about_ca_topic_score_gemma":0.01085666,"domain_scores_codex":[0.9995345,0.00008685164,0.00003251313,0.0001485846,0.00009594367,0.0001016032],"domain_scores_gemma":[0.9990051,0.000339888,0.0003498088,0.00004816662,0.00007052761,0.0001865554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001538097,0.00003075163,0.9798403,0.0000146876,0.00003485232,0.01274744,0.0005143338,0.00008579415,0.002550462,0.00004021597,0.0001393031,0.003848032],"study_design_scores_gemma":[0.0000246268,0.0001682254,0.9440976,0.00001598384,0.00006861587,0.05363895,0.0005315442,0.0002898688,0.0007262349,0.000068421,0.0003588898,0.00001107398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996777,0.00009653106,0.00005181898,0.000009775845,0.000001225893,0.000002395498,0.00003288018,0.000003422389,0.0001242952],"genre_scores_gemma":[0.9997482,0.00005420632,0.00007841613,0.000008100866,0.000003508647,0.000002815687,0.00004929469,0.000001516451,0.00005404692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00831055,"threshold_uncertainty_score":0.01652437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110070580457876,"score_gpt":0.2553013785443405,"score_spread":0.2442943204985529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}