{"id":"W1979502707","doi":"10.1021/bi802043h","title":"Structural Domains and Main-Chain Flexibility in Prion Proteins","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"","keywords":"Flexibility (engineering); Chain (unit); Chemistry; Prion protein; Prion Proteins; Polypeptide chain; Computational biology; Biophysics; Cell biology; Biochemistry; Biology; Physics; Amino acid; Mathematics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143614,0.0002101198,0.0001542148,0.0003540769,0.0001779609,0.0002346986,0.0001937423,0.0001761625,0.0002804563],"category_scores_gemma":[0.0004152241,0.0001225547,0.000195852,0.0001934071,0.0003643355,0.0003479135,0.0002402096,0.0002846837,0.00005775719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001323597,"about_ca_system_score_gemma":0.0001046666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004681705,"about_ca_topic_score_gemma":0.0006297703,"domain_scores_codex":[0.9999466,0.000009542889,0.000003072734,0.00001531716,0.00001932681,0.000006085389],"domain_scores_gemma":[0.9998245,0.00007286846,0.00004687195,0.00001977738,0.00001542333,0.00002072562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714617,0.0000440172,0.01642346,0.0001352471,0.00004039635,0.0002814022,0.0002814371,0.07884057,0.8870521,0.005476008,0.00005388088,0.01120011],"study_design_scores_gemma":[0.00003461361,0.0005615825,0.1666932,0.0000531393,0.00006464157,0.002406498,0.0004344839,0.5067528,0.3017476,0.01838388,0.002785457,0.00008208083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669948,0.0005892239,0.03177086,0.00002164266,0.00000369533,0.000008801122,0.00002802849,0.00003656295,0.0005464395],"genre_scores_gemma":[0.992316,0.00009132004,0.007465771,0.000004864004,0.000002105765,0.000004748294,0.00003519828,0.000006995246,0.00007294346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004681705,"threshold_uncertainty_score":0.0009604096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008369299263796554,"score_gpt":0.2565684253346825,"score_spread":0.2481991260708859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}