{"id":"W1979513688","doi":"10.1897/05-520r.1","title":"Exposure to 3,3′,4,4′,5-pentachlorobiphenyl during embryonic development has a minimal effect on the cytochrome P4501A response to 2,3,7,8-tetrachlorodibenzo-<i>P</i>-dioxin in cultured chicken embryo hepatocytes","year":2006,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Carleton University; Environment and Climate Change Canada","funders":"","keywords":"In ovo; Hepatocyte; Incubation; Cytochrome P450; In vitro; Embryo; Andrology; Biology; Embryogenesis; Embryonic stem cell; Cytochrome; Microsome; Chemistry; Internal medicine; Molecular biology; Biochemistry; Cell biology; Metabolism; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009646986,0.0002701318,0.000171183,0.0001284906,0.0001204943,0.0002710016,0.0001584616,0.0001888567,0.001368449],"category_scores_gemma":[0.0001503013,0.0002325606,0.0001707746,0.00009836187,0.0003054037,0.0001301998,0.0001513053,0.0004202756,0.0002919223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388844,"about_ca_system_score_gemma":0.0002993942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004079289,"about_ca_topic_score_gemma":0.007590955,"domain_scores_codex":[0.9998108,0.00002862135,0.00002033442,0.00007037257,0.00003443479,0.00003543864],"domain_scores_gemma":[0.9998012,0.00005831821,0.00004785747,0.00002354202,0.00003187371,0.00003723804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002320511,0.00001132812,0.0005882247,0.00001684657,0.000004249941,0.00003344703,0.00002781204,0.00002716324,0.9984194,0.00001525822,0.00001949525,0.0006046307],"study_design_scores_gemma":[0.000008691232,0.0006999591,0.02217503,0.000005272826,0.00001541547,0.0001166834,0.00007767701,0.0001675486,0.9756216,0.00001390482,0.001093105,0.000005096727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969975,0.0005128853,0.0008381571,0.00005084933,0.00002164403,0.00001627392,0.0003343533,0.00002795261,0.001200521],"genre_scores_gemma":[0.9913619,0.0005325639,0.001499801,0.00008421943,0.000006549299,0.000047377,0.001086265,0.00002154312,0.005359818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004079289,"threshold_uncertainty_score":0.00811106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00515968813817203,"score_gpt":0.1951673392889847,"score_spread":0.1900076511508127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}