{"id":"W1979563849","doi":"10.1016/j.ejphar.2011.02.003","title":"Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator","year":2011,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"AstraZeneca","keywords":"Allosteric modulator; Allosteric regulation; Agonist; NMDA receptor; Glutamatergic; Chemistry; Metabotropic glutamate receptor; Pharmacology; Long-term potentiation; Glutamate receptor; Neuroscience; Receptor; Cell biology; Biophysics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001288237,0.0002329192,0.0005023259,0.0003484466,0.0001236492,0.00001715545,0.001226257,0.00004322597,0.001483548],"category_scores_gemma":[0.0005384182,0.0001893607,0.0002469507,0.0005174032,0.0008077289,0.0003935408,0.000365558,0.0008031795,0.0001977438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002722712,"about_ca_system_score_gemma":0.0001703816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.970275e-7,"about_ca_topic_score_gemma":4.777119e-8,"domain_scores_codex":[0.9948794,0.002613413,0.001045809,0.0004534993,0.0004644943,0.0005434375],"domain_scores_gemma":[0.9978718,0.0004625028,0.0009283178,0.0001805449,0.0002635317,0.0002933617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001554703,0.001169177,0.0001806885,0.00001824399,0.00003925024,0.001048514,0.0003329854,0.00001195832,0.9924626,0.00007472932,0.001833359,0.001273809],"study_design_scores_gemma":[0.002976307,0.003353637,0.003882758,0.00001927452,0.00009648542,0.0006176406,0.00001382167,0.0002402928,0.9862676,0.000009429159,0.002367289,0.0001554128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932436,0.00007096338,0.0002741075,0.0004303028,0.003124639,0.0003343,0.00004230376,0.00002622437,0.002453553],"genre_scores_gemma":[0.9957913,0.0002662542,0.0009484255,0.002221749,0.0003592389,0.000004201032,1.920157e-7,0.00004882271,0.0003598335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00619493,"threshold_uncertainty_score":0.9994292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1410969868353185,"score_gpt":0.3793287452653549,"score_spread":0.2382317584300365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}