{"id":"W1979582699","doi":"10.1371/journal.ppat.1000829","title":"An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; McMaster University","keywords":"TLR3; Extracellular; RNA silencing; Biology; Cell biology; Receptor; Interferon; Innate immune system; Signal transduction; RNA interference; RNA; Toll-like receptor; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001966218,0.0004201369,0.000260422,0.0001604529,0.0001641687,0.0002760426,0.000217856,0.0003006797,0.00243922],"category_scores_gemma":[0.0001507592,0.0001234826,0.0002904265,0.0001139028,0.0002245332,0.0002333798,0.0002513305,0.0004907266,0.00108388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517783,"about_ca_system_score_gemma":0.0002338494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003511099,"about_ca_topic_score_gemma":0.0004997181,"domain_scores_codex":[0.9998164,0.0000402382,0.00001895476,0.0000457305,0.00004576924,0.00003300882],"domain_scores_gemma":[0.9998265,0.00001938562,0.00006983261,0.00001648359,0.0000239021,0.00004384068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007473122,0.00000666705,0.0001558372,0.00003645594,0.000002256182,0.00005673293,0.000005458213,0.00001996655,0.9985973,0.00008839279,0.00003444217,0.0009217357],"study_design_scores_gemma":[0.00002104165,0.0005077358,0.004717093,0.000009831522,0.00002511015,0.001615923,0.00003025513,0.0009029462,0.9832318,0.0001226397,0.008805381,0.00001028946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981386,0.003103828,0.01100429,0.0002527437,0.0001173332,0.00007842144,0.0005928145,0.000304133,0.00316038],"genre_scores_gemma":[0.9744356,0.0008729408,0.01395274,0.0001723827,0.00003966433,0.00005734898,0.001299916,0.00005864809,0.009110955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00243922,"threshold_uncertainty_score":0.008160055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812008334833694,"score_gpt":0.2699554674596676,"score_spread":0.2518353841113307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}