{"id":"W1979585641","doi":"10.1038/clpt.2013.122","title":"Profiling Serum Bile Acid Glucuronides in Humans: Gender Divergences, Genetic Determinants, and Response to Fenofibrate","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Heart, Lung, and Blood Institute; Canadian Liver Foundation; Canadian Institutes of Health Research; Health Canada; Institut Universitaire de France; National Institutes of Health","keywords":"UGT2B7; Glucuronidation; Fenofibrate; Chenodeoxycholic acid; Glucuronosyltransferase; Chemistry; Internal medicine; Bile acid; Endocrinology; Pharmacology; Biochemistry; Enzyme; Biology; Microsome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007578,0.0001905047,0.0003144685,0.0003942604,0.0001805706,0.0002449233,0.00007835005,0.0002096239,0.0009612321],"category_scores_gemma":[0.0005814828,0.0001173452,0.0001496619,0.0002797524,0.0001863903,0.0001104286,0.000139986,0.0001564352,0.0001598784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287519,"about_ca_system_score_gemma":0.00008176254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006740411,"about_ca_topic_score_gemma":0.0006396375,"domain_scores_codex":[0.999823,0.00005113428,0.00001372081,0.00006006525,0.00002676891,0.0000252575],"domain_scores_gemma":[0.9998362,0.00003107618,0.00005424176,0.00002369068,0.00001922801,0.00003554623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004697283,0.0001140606,0.8956049,0.00003904522,0.0001373611,0.0005574035,0.0003081998,0.00009582584,0.08011322,0.00009767215,0.000155496,0.01807961],"study_design_scores_gemma":[0.00001757313,0.0006429818,0.9926147,0.000003130472,0.00003986604,0.001239735,0.0001339061,0.0001459073,0.004710031,0.00007256419,0.0003741632,0.000005338918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991266,0.0003261688,0.0001585249,0.0000168684,0.000003028585,0.000003679545,0.0001278443,0.000003121423,0.0002342668],"genre_scores_gemma":[0.9993733,0.00009627829,0.0001323924,0.00003205265,0.00000369146,0.000004494844,0.0001419667,0.000003481896,0.0002124634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009612321,"threshold_uncertainty_score":0.003215671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07475749646715302,"score_gpt":0.3924157924352398,"score_spread":0.3176582959680868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}