{"id":"W1979607272","doi":"10.1074/jbc.m112.342238","title":"Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Lysosome; Cell biology; Endosome; Apoptosis; Biology; Small hairpin RNA; Programmed cell death; Gene knockdown; Biochemistry; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309521,0.0003938494,0.000238987,0.0002424916,0.0002071316,0.0003492794,0.0001199545,0.0002186934,0.001365063],"category_scores_gemma":[0.0001119354,0.0001587129,0.0002836748,0.0002053211,0.0002022195,0.0002392722,0.0002648679,0.0003753581,0.0004980961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000480154,"about_ca_system_score_gemma":0.0003405988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003384852,"about_ca_topic_score_gemma":0.0005714695,"domain_scores_codex":[0.9997841,0.00003462833,0.0000303449,0.00003799691,0.00006330249,0.00004960502],"domain_scores_gemma":[0.999922,0.000006570627,0.0000285399,0.0000123056,0.00001163824,0.0000188741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001408872,0.00002300602,0.0003422921,0.00006385798,0.000008008519,0.0001484267,0.00001739253,0.00007442792,0.9975196,0.0002143002,0.0001149262,0.001332893],"study_design_scores_gemma":[0.00003130932,0.0002535998,0.004241013,0.000005817382,0.00001258806,0.0008300069,0.00003346243,0.0008885859,0.9891632,0.00006883594,0.004466239,0.000005286819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894062,0.002432618,0.003905595,0.0001974148,0.00005655623,0.00005260522,0.0005562583,0.0001901346,0.003202544],"genre_scores_gemma":[0.9911934,0.001522149,0.00241675,0.00006014832,0.00001492937,0.00004680855,0.0008506958,0.0000119854,0.003883166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365063,"threshold_uncertainty_score":0.00456661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323127188993352,"score_gpt":0.231354220851364,"score_spread":0.2181229489614305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}