{"id":"W1979623506","doi":"10.1016/j.matbio.2015.01.018","title":"EMMPRIN, an upstream regulator of MMPs, in CNS biology","year":2015,"lang":"en","type":"review","venue":"Matrix Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Matrix metalloproteinase; Regulator; Metalloproteinase; Neuroscience; Homeostasis; Central nervous system; Integrin; Multiple sclerosis; Cell adhesion molecule; Extracellular matrix; Medicine; Immunology; Biology; Cell biology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006530212,0.0005317025,0.001672861,0.0002378612,0.00002404174,0.00000768866,0.0008962026,0.001530904,0.00005719095],"category_scores_gemma":[0.0002924847,0.000449281,0.0004091295,0.0002575362,0.0003529046,0.000002464612,0.0003923548,0.0002741309,0.00004286503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006017532,"about_ca_system_score_gemma":0.0007361759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006463311,"about_ca_topic_score_gemma":0.00002960361,"domain_scores_codex":[0.9967909,0.0007708409,0.0009242833,0.0009305241,0.00007559268,0.0005078661],"domain_scores_gemma":[0.9978263,0.00005184293,0.0005373833,0.001248253,0.0001330741,0.0002031143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002451888,0.0009052817,0.004501082,0.006754388,0.0006916884,0.00003749265,0.00006999607,0.00001351125,0.01388432,0.005120967,0.003386545,0.9643896],"study_design_scores_gemma":[0.0004477428,0.000639602,0.000008307402,0.00042108,0.0001818746,0.00003927518,0.00001235123,0.00000160905,0.001056176,0.0009029033,0.9958131,0.0004760237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006921096,0.9909216,0.00005185162,0.000007992298,0.0004147662,0.0005611553,0.0006868814,0.00002794221,0.0004067556],"genre_scores_gemma":[0.006410489,0.9875628,0.000608671,0.00003660829,0.0005849607,0.000135367,0.004265825,0.0001025231,0.0002927484],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924265,"threshold_uncertainty_score":0.9997959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05639088614204475,"score_gpt":0.4075042400504199,"score_spread":0.3511133539083752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}