{"id":"W1979670456","doi":"10.1074/jbc.m109.077180","title":"Analysis of Transmembrane Domains 1 and 4 of the Human Angiotensin II AT1 Receptor by Cysteine-scanning Mutagenesis","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Transmembrane domain; Cysteine; Mutant; Receptor; Transmembrane protein; Mutagenesis; Angiotensin II; Chemistry; Biochemistry; Context (archaeology); Molecular biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512175,0.0005736382,0.0003963395,0.0002383514,0.0001761366,0.0002400411,0.0005484575,0.0004076582,0.0009869058],"category_scores_gemma":[0.0003092139,0.000211442,0.0006258421,0.000232589,0.000204334,0.000121131,0.0002426552,0.0005575569,0.0004817588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004574066,"about_ca_system_score_gemma":0.0003668282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186472,"about_ca_topic_score_gemma":0.001979319,"domain_scores_codex":[0.9997098,0.0001051255,0.00003063232,0.00004190205,0.00007001096,0.00004262398],"domain_scores_gemma":[0.999826,0.00005676347,0.00006009465,0.00001238001,0.00002303049,0.00002183532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003361461,0.00004284202,0.0003085914,0.0000717098,0.00002068948,0.00029408,0.00003701376,0.0005680204,0.9965269,0.0002366409,0.00006094202,0.001496431],"study_design_scores_gemma":[0.000118681,0.0004908313,0.00648835,0.00002497594,0.0001289415,0.001616251,0.00008941464,0.007537173,0.9771215,0.000118101,0.006232607,0.00003317672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888716,0.0009839182,0.007813297,0.0001372857,0.0000633391,0.0001403367,0.0007864045,0.00006352081,0.001140279],"genre_scores_gemma":[0.9850858,0.00110331,0.01066838,0.00008334903,0.00001985763,0.00007435483,0.001424476,0.00003931324,0.001501131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186472,"threshold_uncertainty_score":0.003707767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059847232741615,"score_gpt":0.2374465567598894,"score_spread":0.2268480844324732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}