{"id":"W1979672191","doi":"10.1016/j.transproceed.2004.10.086","title":"Sirolimus upregulates aP2 expression in human monocytes and macrophages","year":2004,"lang":"en","type":"article","venue":"Transplantation Proceedings","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Sirolimus; FKBP; Mycophenolate; Downregulation and upregulation; Endocrinology; Internal medicine; Biology; Mechanistic target of rapamycin; Mycophenolic acid; Lipolysis; Lipid metabolism; Messenger RNA; PI3K/AKT/mTOR pathway; Chemistry; Cell biology; Adipose tissue; Transplantation; Biochemistry; Signal transduction; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147097,0.000226983,0.0002592868,0.0003076093,0.0002257609,0.0004057157,0.00008532283,0.0002068725,0.002085119],"category_scores_gemma":[0.0000965155,0.0001476601,0.0002746785,0.0002447533,0.0001166383,0.0001533093,0.0001742939,0.0004231443,0.0006973965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238072,"about_ca_system_score_gemma":0.0001474702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005384432,"about_ca_topic_score_gemma":0.0006621113,"domain_scores_codex":[0.9998357,0.00003764992,0.00001546113,0.00001882497,0.00003036386,0.00006193903],"domain_scores_gemma":[0.9999405,0.00001359465,0.000007205113,0.000008308011,0.00001396721,0.00001653349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001260611,0.00004955376,0.0005202804,0.00004833127,0.000009054247,0.0001575114,0.00006389743,0.00002670208,0.9954086,0.00007145828,0.0001033238,0.002280603],"study_design_scores_gemma":[0.0001668142,0.001396137,0.03471493,0.00001410233,0.00007782948,0.0007428779,0.0004289669,0.0006227623,0.9550312,0.0001322103,0.006660042,0.00001212435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994388,0.002449062,0.0006888735,0.00009401351,0.00005984714,0.00001802094,0.0002843723,0.00003205835,0.001985681],"genre_scores_gemma":[0.9918069,0.001595163,0.0007368405,0.0001052019,0.00006499987,0.00005393538,0.0007090689,0.000009355585,0.00491846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085119,"threshold_uncertainty_score":0.006975412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00632486455011111,"score_gpt":0.2378949523099099,"score_spread":0.2315700877597988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}