{"id":"W1979678438","doi":"10.1016/j.coph.2005.03.004","title":"mTOR — beyond transplantation","year":2005,"lang":"en","type":"review","venue":"Current Opinion in Pharmacology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors; Transplantation; Sirolimus; Cell biology; Kinase; Cancer research; Cell growth; Signal transduction; Chemistry; Biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009223906,0.0008008135,0.001550863,0.0008960637,0.0003803609,0.001451044,0.0009628416,0.001705591,0.004699534],"category_scores_gemma":[0.0005577386,0.0002234769,0.0004311288,0.000815446,0.00113429,0.002361508,0.0007439074,0.004798739,0.004309224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008169794,"about_ca_system_score_gemma":0.001072699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004867591,"about_ca_topic_score_gemma":0.001095671,"domain_scores_codex":[0.9998066,0.00003804207,0.00002161736,0.00004136594,0.00006574579,0.00002668036],"domain_scores_gemma":[0.9998425,0.00005681851,0.00001822705,0.00001047414,0.00004150502,0.00003040293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002715793,0.0001069465,0.000140299,0.002934047,0.00006064066,0.0003445625,0.00003900996,0.0003365628,0.002629777,0.02698714,0.1568245,0.809325],"study_design_scores_gemma":[0.00006193154,0.00007892511,0.0002539247,0.0005404881,0.00003381699,0.0005994983,0.00002235371,0.000103751,0.0005096471,0.006601022,0.9911842,0.00001046948],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003233009,0.9789962,0.000731766,0.006839909,0.005466174,0.00001158844,0.00003707906,0.00005212655,0.007541935],"genre_scores_gemma":[0.005020982,0.9651248,0.0008603657,0.008919587,0.007972616,0.0000400555,0.00009894856,0.0000163765,0.01194631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004699534,"threshold_uncertainty_score":0.0157215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08502665558380847,"score_gpt":0.4517679934027507,"score_spread":0.3667413378189422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}