{"id":"W1979690693","doi":"10.1161/01.res.0000258022.13090.55","title":"Ca <sup>2+</sup> /Calmodulin Kinase II-Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca <sup>2+</sup> Sparks and Ca <sup>2+</sup> Waves in Cardiac Myocytes","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institutes of Health","keywords":"Phospholamban; Ryanodine receptor; Ryanodine receptor 2; Endoplasmic reticulum; Calmodulin; Phosphorylation; Extracellular; Internal medicine; Endocrinology; Chemistry; Myocyte; Calcium; Protein kinase A; Biology; Molecular biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004025875,0.0006386132,0.001414035,0.001453992,0.0006569977,0.00008745171,0.0003024241,0.0008528519,0.001145242],"category_scores_gemma":[0.001890216,0.000635928,0.0004252257,0.001655345,0.000794279,0.0004942516,0.0003573538,0.001782409,0.0001498125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007131398,"about_ca_system_score_gemma":0.0005844863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002422699,"about_ca_topic_score_gemma":0.00006141741,"domain_scores_codex":[0.9927719,0.001035555,0.00136257,0.001384549,0.001816256,0.001629177],"domain_scores_gemma":[0.9954532,0.001441073,0.0002398744,0.001124061,0.001121478,0.0006202974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00549433,0.001261388,0.09238644,0.001389691,0.0009958149,0.0009571518,0.02170542,0.8146684,0.02728443,0.0006072546,0.014877,0.01837267],"study_design_scores_gemma":[0.01311669,0.003051704,0.2135569,0.001478869,0.0006554156,0.0004750213,0.01575934,0.6647009,0.0699981,0.001973013,0.01281999,0.002414054],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905064,0.003911758,0.0001789077,0.00119336,0.0001683916,0.001955462,0.0001470157,0.00009818879,0.001840529],"genre_scores_gemma":[0.9950977,0.001096956,0.0002640888,0.0001471498,0.00100873,0.0001298985,0.000993304,0.0001152519,0.001146896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1499675,"threshold_uncertainty_score":0.9997678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02493059796629132,"score_gpt":0.3126997247368656,"score_spread":0.2877691267705743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}