{"id":"W1979690693","doi":"10.1161/01.res.0000258022.13090.55","title":"Ca <sup>2+</sup> /Calmodulin Kinase II-Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca <sup>2+</sup> Sparks and Ca <sup>2+</sup> Waves in Cardiac Myocytes","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institutes of Health","keywords":"Phospholamban; Ryanodine receptor; Ryanodine receptor 2; Endoplasmic reticulum; Calmodulin; Phosphorylation; Extracellular; Internal medicine; Endocrinology; Chemistry; Myocyte; Calcium; Protein kinase A; Biology; Molecular biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391895,0.0003148931,0.0003893718,0.00009835915,0.000118334,0.00031186,0.0002710835,0.0002091535,0.0007257866],"category_scores_gemma":[0.000174828,0.0001432147,0.00020092,0.00009183271,0.0002854077,0.0001911371,0.0001810459,0.0005448104,0.0002444285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001808671,"about_ca_system_score_gemma":0.0002647924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004141619,"about_ca_topic_score_gemma":0.0006517759,"domain_scores_codex":[0.9998651,0.00001834355,0.00001943346,0.00002660412,0.00002702844,0.00004354386],"domain_scores_gemma":[0.9998714,0.00001874757,0.00003573579,0.00001997365,0.000008641086,0.00004549286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002533885,0.0000372323,0.0001032535,0.00002532389,0.000003237123,0.00003017821,0.00001173078,0.00002364815,0.9987817,0.00003417247,0.00002465979,0.0006714977],"study_design_scores_gemma":[0.0001025171,0.0007059611,0.007309852,0.000008387959,0.00002341784,0.0002086935,0.00005221074,0.001112462,0.9891584,0.00004649245,0.001265734,0.000005918625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980738,0.0006021904,0.0005818021,0.00004502889,0.00002341365,0.00001422273,0.00009636122,0.00003704004,0.0005259767],"genre_scores_gemma":[0.9973098,0.0003700874,0.0006841957,0.00004544954,0.00001567138,0.00003709109,0.0002652428,0.00002134684,0.001251072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007257866,"threshold_uncertainty_score":0.002427936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02493059796629132,"score_gpt":0.3126997247368656,"score_spread":0.2877691267705743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}