{"id":"W1979709562","doi":"10.3747/co.19.1149","title":"Biomarkers That Currently Affect Clinical Practice: EGFR, ALK, MET, KRAS","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; London Health Sciences Centre","funders":"","keywords":"KRAS; Crizotinib; Medicine; Pemetrexed; Lung cancer; Epidermal growth factor receptor; Anaplastic lymphoma kinase; EGFR inhibitors; Oncology; Targeted therapy; Biomarker; Cancer research; Cetuximab; Internal medicine; Cancer; Chemotherapy; Colorectal cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008177626,0.000215256,0.0004907111,0.0001213757,0.0001062837,0.00001399505,0.0000974107,0.0001801532,0.000381423],"category_scores_gemma":[0.0006931007,0.0001639503,0.0002481974,0.0001968223,0.0001745971,0.0002899185,0.00006996633,0.0003948036,0.0005043458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005170788,"about_ca_system_score_gemma":0.000475651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001895699,"about_ca_topic_score_gemma":0.000005709558,"domain_scores_codex":[0.9981212,0.0003421725,0.000411756,0.0003331142,0.000269455,0.0005223267],"domain_scores_gemma":[0.9979948,0.0007888938,0.0002612486,0.0003455074,0.0001379093,0.0004716054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002882536,0.004019545,0.3837985,0.0000695905,0.0008022534,0.00002926827,0.0005023701,1.417482e-7,0.00002605515,0.0007429576,0.08078151,0.5289395],"study_design_scores_gemma":[0.003932326,0.001049711,0.09372846,0.00006581679,0.001898598,0.0001732269,0.0004788821,0.00001286588,0.00006023594,0.00002936995,0.898422,0.0001484814],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5825524,0.1212573,0.001922317,0.01562455,0.05673479,0.004088168,0.0001105048,0.0005325117,0.2171774],"genre_scores_gemma":[0.9909254,0.002431467,0.003150036,0.0008332917,0.001826517,0.0001783687,0.0002143829,0.00003684899,0.0004036943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8176405,"threshold_uncertainty_score":0.66857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2188586083102059,"score_gpt":0.5815272708993818,"score_spread":0.362668662589176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}