{"id":"W1979710854","doi":"10.1074/jbc.m112.405738","title":"Mitochondrial Glutathione Transport Is a Key Determinant of Neuronal Susceptibility to Oxidative and Nitrosative Stress","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Glutathione; Mitochondrion; Oxidative stress; Cell biology; Reactive oxygen species; Oxidative phosphorylation; Biochemistry; Cytosol; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304164,0.0001706694,0.0003433196,0.00002374908,0.00003656015,0.000008606802,0.0001761834,0.0002688333,0.0003727605],"category_scores_gemma":[0.000305083,0.0001205646,0.0001640716,0.00006661718,0.0002133111,0.000007353444,0.000066128,0.000205549,0.000003490749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001068701,"about_ca_system_score_gemma":0.00006225599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001065053,"about_ca_topic_score_gemma":0.000003475438,"domain_scores_codex":[0.9987982,0.00007926441,0.0005076946,0.0002899262,0.0001380679,0.0001868746],"domain_scores_gemma":[0.9989602,0.00004600837,0.000302635,0.0001665794,0.0003171046,0.0002074564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006140881,0.0001163332,0.01313686,0.00002282515,0.00003657052,0.000007765531,0.0001316499,0.000003401981,0.9845123,0.000001936497,0.0005289442,0.0008872739],"study_design_scores_gemma":[0.0007236631,0.001278274,0.02283213,0.00002164076,0.00001947125,0.00008248042,0.000202096,0.000002458742,0.973016,0.0001080157,0.001575135,0.0001385839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976146,0.0001085263,0.001423902,0.000251971,0.0001733955,0.0001552929,0.0000860885,0.000002876957,0.0001833065],"genre_scores_gemma":[0.9964837,0.00008430952,0.002583039,0.0002692088,0.0004106071,0.000007785066,0.00002402793,0.000006238682,0.000131047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01149629,"threshold_uncertainty_score":0.491648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564806212207989,"score_gpt":0.2497575466918968,"score_spread":0.2341094845698169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}