{"id":"W1979729122","doi":"10.1016/s0024-3205(01)01241-3","title":"L-NAME prevents in vivo the inactivation but not the down-regulation of hepatic cytochrome P450 caused by an acute inflammatory reaction","year":2001,"lang":"en","type":"article","venue":"Life Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Novartis Pharma","keywords":"In vivo; Cytochrome P450; Pharmacology; Chemistry; Cytochrome; Medicine; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000686667,0.001269423,0.001452132,0.0006194719,0.0005415623,0.0006768587,0.0006109506,0.001002246,0.003209354],"category_scores_gemma":[0.00101442,0.0005148977,0.0007726682,0.0003422721,0.001467934,0.0009886412,0.0004270383,0.002911133,0.001040473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003664927,"about_ca_system_score_gemma":0.0009381022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005173418,"about_ca_topic_score_gemma":0.000822792,"domain_scores_codex":[0.9993891,0.0001846656,0.00006138564,0.00006424025,0.00009634705,0.0002042577],"domain_scores_gemma":[0.9982544,0.0003704459,0.0004271826,0.0002777163,0.0001268814,0.0005433797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009894769,0.0009585675,0.0005107781,0.0001635715,0.00004008163,0.0004344099,0.0000868233,0.0002227151,0.9829798,0.0003873851,0.0002941761,0.004026914],"study_design_scores_gemma":[0.0004041542,0.00571309,0.004262778,0.00001680197,0.00006124075,0.0006203101,0.00006502328,0.0009357394,0.9866602,0.0001436631,0.001098904,0.00001807656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866572,0.002979999,0.006208316,0.0007621826,0.0003900834,0.00008948173,0.0004375334,0.00051081,0.00196436],"genre_scores_gemma":[0.9921315,0.001185762,0.002113692,0.0001595274,0.0002183548,0.00008514083,0.0006473851,0.00007658733,0.003382058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003209354,"threshold_uncertainty_score":0.01073635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0739610474471642,"score_gpt":0.3999660705482856,"score_spread":0.3260050231011214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}