{"id":"W1979735443","doi":"10.1111/j.1399-0004.2011.01767.x","title":"The accuracy of risks for cancer in Lynch syndrome","year":2011,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lynch syndrome; MSH6; MLH1; Germline mutation; MSH2; Medicine; Colorectal cancer; Genetic counseling; Cancer; Genetics; Oncology; Internal medicine; Mutation; Biology; Gene; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007443639,0.000327033,0.001022959,0.00007984128,0.00004593096,0.00001261907,0.0005865033,0.001494937,0.0002478519],"category_scores_gemma":[0.002257092,0.0002272218,0.0004834968,0.0001686051,0.0005699177,0.000008475144,0.0001667527,0.002012507,0.00001913721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038802,"about_ca_system_score_gemma":0.0007995997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009864989,"about_ca_topic_score_gemma":0.0001538136,"domain_scores_codex":[0.9968331,0.0001600455,0.001512992,0.0005592142,0.0003989376,0.0005356594],"domain_scores_gemma":[0.9936579,0.004252977,0.0006188256,0.001036515,0.000328357,0.0001054415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004242615,0.0001473649,0.06014843,0.000754101,0.0003766265,0.0001061954,0.00008639324,0.00001862993,0.00003610145,0.000004563978,0.8683015,0.06959585],"study_design_scores_gemma":[0.001387296,0.001457308,0.1068131,0.0003831052,0.0004168746,0.0000234874,0.00001002715,0.0001334125,0.0003052064,0.0007536883,0.888042,0.0002744402],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6052508,0.03289956,0.0001817914,0.3363441,0.0150912,0.00716817,0.000774578,0.00007134638,0.002218366],"genre_scores_gemma":[0.3856785,0.05712439,0.009790554,0.5244219,0.009816437,0.001893452,0.0002124971,0.0005439469,0.01051832],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2195723,"threshold_uncertainty_score":0.9998013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.251877324010763,"score_gpt":0.472099689774845,"score_spread":0.220222365764082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}