{"id":"W1979754115","doi":"10.1182/blood-2011-11-393272","title":"Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; University of Toronto; Ontario Institute for Cancer Research; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Cytokinesis; Biology; Stem cell; Cell biology; Asymmetric cell division; Progenitor cell; Cell division; Haematopoiesis; Cell fate determination; Hematopoietic stem cell; Cell; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172322,0.0001390868,0.000270776,0.000157432,0.0000293888,0.000008157683,0.00003465208,0.0000730641,0.00001218623],"category_scores_gemma":[0.000005842241,0.0001085905,0.00002426,0.000242747,0.00006101979,0.00005667718,0.0000113656,0.00006745696,0.000005623292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001061553,"about_ca_system_score_gemma":0.0000663875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002244506,"about_ca_topic_score_gemma":0.000003486925,"domain_scores_codex":[0.9991075,0.00003301476,0.0002461915,0.0002232789,0.0002321888,0.0001578658],"domain_scores_gemma":[0.9994478,0.00007455792,0.0001060034,0.0001676122,0.00007669036,0.0001273786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001020053,0.006395885,0.757256,0.01782879,0.001920934,0.0008034473,0.03760489,9.287862e-7,0.1656022,0.003629223,0.00003087408,0.00790677],"study_design_scores_gemma":[0.006151127,0.001009847,0.01863923,0.0003271372,0.001328887,0.001535126,0.0005333993,0.00003946625,0.9701589,0.0001001457,0.00001180395,0.0001648854],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965059,0.0005228784,0.000190426,0.00001036351,0.00003011861,0.0005810338,0.000005098102,0.0000572136,0.002097004],"genre_scores_gemma":[0.9911824,0.0001148512,0.0085522,0.0000112501,0.00002125652,0.00002405577,0.000004223607,0.00002255655,0.00006715149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8045568,"threshold_uncertainty_score":0.4428191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536480160844839,"score_gpt":0.2091339945245124,"score_spread":0.193769192916064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}