{"id":"W1979761537","doi":"10.1085/jgp.200910288","title":"A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data","year":2010,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Homology modeling; Chemistry; Potassium channel; Calcium; Calcium channel; Potassium; Biophysics; Crystallography; Voltage-dependent calcium channel; In silico; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873646,0.0001120912,0.0002369042,0.00003798176,0.00006902334,0.000002459504,0.0005058569,0.00013851,0.0000439361],"category_scores_gemma":[0.00003560182,0.00005665157,0.00008735014,0.00008736397,0.0004118491,0.000006747178,0.0002056629,0.0001975799,0.000001224599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004730702,"about_ca_system_score_gemma":0.0001798605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003501538,"about_ca_topic_score_gemma":0.00002720167,"domain_scores_codex":[0.9991341,0.0001199659,0.0003346658,0.000137626,0.0001260568,0.0001475474],"domain_scores_gemma":[0.9984576,0.00001569322,0.0005395831,0.0006115841,0.0003361696,0.00003935704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006714935,0.00006753303,0.00004171335,0.00001046316,0.0001117669,3.600599e-7,0.00009530298,0.005994556,0.981053,0.00009710844,0.011812,0.00004469865],"study_design_scores_gemma":[0.001921266,0.001133177,0.00135682,0.00002089488,0.0001513438,0.0004047185,0.0002076073,0.0350109,0.9538683,0.001859368,0.003887309,0.0001783147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995246,0.0001256428,0.003276468,0.0006251035,0.0004108829,0.0001066528,0.00005761179,0.000001511536,0.0001501625],"genre_scores_gemma":[0.9977293,0.00004626896,0.0004212536,0.0004540117,0.0003280133,9.824695e-7,0.00004532709,0.00001169145,0.0009631769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02901634,"threshold_uncertainty_score":0.2310184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03166445001356671,"score_gpt":0.2508586033566952,"score_spread":0.2191941533431285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}