{"id":"W1979766141","doi":"10.1016/j.tetlet.2004.02.078","title":"Synthesis of the substituted spiro segment of halichlorine––use of radical cyclization and stereospecific cuprate addition to an α,β-unsaturated lactam","year":2004,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Oxidative Organic Chemistry Reactions","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Stereospecificity; Lactam; Cuprate; Radical cyclization; Stereochemistry; Beta-lactam; Combinatorial chemistry; Organic chemistry; Catalysis; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007087366,0.0001713773,0.0002533966,0.00005827653,0.00004864678,0.00001583188,0.0001750227,0.00009302362,0.0002967248],"category_scores_gemma":[0.0001827134,0.0001470741,0.00006377041,0.0003264898,0.0002385086,0.0001640997,0.00004129759,0.0001410806,0.00000211324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643491,"about_ca_system_score_gemma":0.00004457114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001715203,"about_ca_topic_score_gemma":0.000027055,"domain_scores_codex":[0.9988546,0.0000272776,0.0004158785,0.0002642394,0.0002812541,0.0001567972],"domain_scores_gemma":[0.9989846,0.00009399729,0.0002923407,0.0004579317,0.00008233851,0.00008881063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006803608,0.000176029,0.002245457,0.0001323655,0.00005450953,0.000001943179,0.0001841231,0.0004932989,0.9959532,0.00006418255,0.000108571,0.0005182652],"study_design_scores_gemma":[0.0004484038,0.00001706727,0.02132455,0.000196694,0.00006894938,0.000008465552,0.0001415961,0.00004268159,0.9773702,0.000007502469,0.0002413206,0.0001325742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982285,0.000006965833,0.0003309459,0.0008606447,0.00004983474,0.0001289944,0.0002232351,0.00003556844,0.0001352933],"genre_scores_gemma":[0.9990271,0.00001088815,0.0007141596,0.00006639444,0.00004727116,0.00001174185,0.00007085216,0.00002355596,0.00002807251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0190791,"threshold_uncertainty_score":0.5997509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984250376180901,"score_gpt":0.2269614874647793,"score_spread":0.2071189837029703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}