{"id":"W1979782687","doi":"10.1038/sj.bjc.6604995","title":"Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts","year":2009,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Medicine; Pancreatic cancer; Ribosomal protein s6; Cancer research; Pharmacology; Internal medicine; Cancer; P70-S6 Kinase 1; Phosphorylation; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006037797,0.0002177988,0.001203144,0.0002269921,0.0001600396,0.00003692594,0.0001799482,0.0001971969,0.0003994804],"category_scores_gemma":[0.0002401794,0.0002172068,0.0002873963,0.0003248419,0.0002882158,0.0002471393,0.0000389312,0.0007417001,0.000003161143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000804977,"about_ca_system_score_gemma":0.002328688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002049571,"about_ca_topic_score_gemma":0.0007052702,"domain_scores_codex":[0.9974239,0.0001162733,0.000794195,0.0002555797,0.0009170334,0.0004930379],"domain_scores_gemma":[0.9980394,0.0001180297,0.00062901,0.0002212119,0.0005858701,0.0004064317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003607172,0.003064255,0.2491557,0.001021812,0.001674268,0.006610229,0.000814135,0.00004300913,0.4166949,0.0001118017,0.01489521,0.3023074],"study_design_scores_gemma":[0.01121829,0.003568684,0.9596993,0.004362892,0.0008248134,0.002997248,0.0001476076,0.00004726285,0.01026615,0.00009438537,0.006425369,0.000347993],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857938,0.00617922,0.00003969733,0.0007254056,0.0002974804,0.0004518325,0.00004387117,0.00001802054,0.006450716],"genre_scores_gemma":[0.9910657,0.004432984,0.0007108092,0.000915415,0.001409613,0.00002233384,0.000008689213,0.00002791333,0.001406547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7105436,"threshold_uncertainty_score":0.8857435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02621350793459556,"score_gpt":0.3437271395326219,"score_spread":0.3175136315980263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}