{"id":"W1979789129","doi":"10.1089/088922200750054684","title":"HIV Type 1 <i>nef</i> Gene Inhibits Tumor Necrosis Factor α-Induced Apoptosis and Promotes Cell Proliferation through the Action of MAPK and JNK in Human Glial Cells","year":2000,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Ceramide; Cell biology; Apoptosis; Biology; Tumor necrosis factor alpha; Programmed cell death; MAPK/ERK pathway; Astrocytosis; Kinase; TRAF2; Transfection; Microglia; Signal transduction; Cell culture; Immunology; Inflammation; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001047361,0.0002340316,0.0001891499,0.0002051027,0.0001163217,0.0001770516,0.0001165889,0.0001348753,0.0006645087],"category_scores_gemma":[0.0001204785,0.00007207088,0.0001781418,0.0001037669,0.0001551166,0.000103152,0.00006152263,0.0002496025,0.0002350982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825912,"about_ca_system_score_gemma":0.0001836171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000810641,"about_ca_topic_score_gemma":0.001258505,"domain_scores_codex":[0.9999449,0.00001177662,0.000005746721,0.000005063654,0.00001168299,0.00002078354],"domain_scores_gemma":[0.9999621,0.000008536092,0.000007056882,0.000006422975,0.000006209991,0.000009666703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004841358,0.0001265722,0.000248786,0.00004484932,0.000006076866,0.0000746284,0.00002564779,0.00006732385,0.9941306,0.00008689336,0.00005905416,0.004645468],"study_design_scores_gemma":[0.00006912156,0.001111422,0.004038868,0.00001074455,0.00001840628,0.0004529576,0.00002516258,0.0005119236,0.9907527,0.00005710096,0.002948457,0.00000320938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953981,0.002546653,0.000710739,0.00004761464,0.00001779219,0.0000203166,0.00009102631,0.00003002657,0.001137735],"genre_scores_gemma":[0.994259,0.001909565,0.001455687,0.00003091553,0.00001062383,0.00003012243,0.0003849172,0.000007894681,0.001911182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000810641,"threshold_uncertainty_score":0.002222955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07320391996301039,"score_gpt":0.3406863580403517,"score_spread":0.2674824380773413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}