{"id":"W1979793180","doi":"10.1002/jps.20080","title":"Assessing the antifungal activity and toxicity profile of amphotericin B lipid complex (ABLC; Abelcet®) in combination with caspofungin in experimental systemic aspergillosis","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Caspofungin; Aspergillus fumigatus; Amphotericin B; Aspergillosis; Toxicity; Pharmacology; Creatinine; Regimen; Medicine; Biology; Internal medicine; Microbiology; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660017,0.000106607,0.0003588512,0.0001370488,0.00009493478,0.000046981,0.0001248075,0.00004238354,0.00003738615],"category_scores_gemma":[0.0001085361,0.00005959243,0.00004771488,0.0005425994,0.0006172306,0.0004775624,0.0000324341,0.0002971277,3.825397e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258935,"about_ca_system_score_gemma":0.0002427483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071991,"about_ca_topic_score_gemma":0.00005672186,"domain_scores_codex":[0.9984769,0.0001592311,0.0004043402,0.0001706958,0.000570044,0.0002188393],"domain_scores_gemma":[0.9993486,0.0001672319,0.0002286306,0.00007126173,0.00008602144,0.00009823944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003093609,0.000500051,0.3329979,0.00007384477,0.000008480756,0.00003559702,0.0003326222,0.00006307098,0.6646252,0.00008102244,0.000002791664,0.000970012],"study_design_scores_gemma":[0.00202229,0.0006680826,0.6508478,0.0004778252,0.00002203054,0.0001970073,0.001838847,0.001653434,0.3421816,0.00002407038,0.000003690547,0.00006335962],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979116,0.0004346892,0.0001790073,0.0008691473,0.00006115399,0.000250675,0.000001579019,0.000003418057,0.0002886769],"genre_scores_gemma":[0.9992105,0.00006313064,0.0005971802,0.00009032308,0.00002931463,0.000001896951,2.385221e-7,0.000003817342,0.000003592383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3224436,"threshold_uncertainty_score":0.2430109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07255513374228377,"score_gpt":0.4037139753536833,"score_spread":0.3311588416113995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}