{"id":"W1979794707","doi":"10.1038/jid.2012.273","title":"Dacarbazine-Mediated Upregulation of NKG2D Ligands on Tumor Cells Activates NK and CD8 T Cells and Restrains Melanoma Growth","year":2012,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Fondation de France; Association pour la Recherche sur le Cancer","keywords":"Cytotoxic T cell; Dacarbazine; NKG2D; Cancer research; CD8; Immune system; Downregulation and upregulation; Melanoma; Immunotherapy; Immunology; Granzyme B; Biology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009166526,0.0002490729,0.0002059006,0.0001763005,0.0001826092,0.000199147,0.0001235602,0.0001447072,0.001698991],"category_scores_gemma":[0.0001125379,0.0001391999,0.0001889363,0.0001162958,0.0001945776,0.0001191278,0.0001462797,0.000684291,0.0003178444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736309,"about_ca_system_score_gemma":0.0002360413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008239908,"about_ca_topic_score_gemma":0.002916176,"domain_scores_codex":[0.9998166,0.00003942427,0.00001042725,0.00002375606,0.00003667555,0.00007317799],"domain_scores_gemma":[0.999948,0.00001195528,0.00001071323,0.00001247634,0.00000391721,0.00001288509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404386,0.00006985741,0.0002951751,0.00002633781,0.000005130927,0.00004804696,0.00001400093,0.0001481986,0.9970492,0.00006438193,0.00009055925,0.001948765],"study_design_scores_gemma":[0.0000524775,0.0007461316,0.008117036,0.000004742124,0.00001744965,0.0003604155,0.00004098137,0.001168283,0.9866971,0.00003718572,0.002753647,0.000004553933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966024,0.0008201494,0.0006877952,0.00006850807,0.00003387859,0.0000191059,0.0001087606,0.00006011768,0.001599272],"genre_scores_gemma":[0.9978511,0.0002586773,0.000519894,0.00001870395,0.000009185303,0.000017692,0.0001241003,0.00000524604,0.001195301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698991,"threshold_uncertainty_score":0.00568372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382144723068816,"score_gpt":0.2236714513095222,"score_spread":0.209850004078834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}