{"id":"W1979809536","doi":"10.1016/j.chom.2009.03.005","title":"Aldolase Is Essential for Energy Production and Bridging Adhesin-Actin Cytoskeletal Interactions during Parasite Invasion of Host Cells","year":2009,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Narodowa Agencja Wymiany Akademickiej","keywords":"Microneme; Biology; Aldolase A; Gliding motility; Bacterial adhesin; Cell biology; Motility; Actin; Cytoskeleton; Fructose-bisphosphate aldolase; Apicomplexa; Cell; Biochemistry; Enzyme; Virulence; Immunology; Plasmodium falciparum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164468,0.0003989276,0.0002363065,0.0002448726,0.0003561784,0.0006610092,0.0002060029,0.0002399022,0.000968291],"category_scores_gemma":[0.0001997434,0.0002060477,0.0001916232,0.0001945909,0.000274887,0.0005250666,0.0003180178,0.0004514302,0.0004077175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004591763,"about_ca_system_score_gemma":0.0002934596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242684,"about_ca_topic_score_gemma":0.001412935,"domain_scores_codex":[0.9998803,0.00002031511,0.00001069866,0.00002492221,0.00002683258,0.00003692004],"domain_scores_gemma":[0.9998536,0.0000215812,0.00002696626,0.00001547463,0.0000376038,0.0000447821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006323681,0.00002733129,0.00136367,0.00005627604,0.00001006246,0.0002498851,0.00003356284,0.00005612944,0.9954105,0.0003556713,0.00006281657,0.001741778],"study_design_scores_gemma":[0.00001137516,0.00005846881,0.01052077,0.000005311467,0.00001590227,0.0005939231,0.00008582073,0.0006412794,0.9851059,0.0002021132,0.002754183,0.000004993441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885119,0.003140817,0.005792807,0.0002332105,0.00007499695,0.00002398398,0.00031329,0.0001108197,0.001798217],"genre_scores_gemma":[0.9936213,0.0006696088,0.002340216,0.00002428253,0.00001115908,0.000007818468,0.0004733394,0.00002442886,0.002827931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242684,"threshold_uncertainty_score":0.003331602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009386100125072173,"score_gpt":0.2553776693814845,"score_spread":0.2459915692564124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}