{"id":"W1979826378","doi":"10.1038/nmeth.2889","title":"Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon","year":2014,"lang":"en","type":"article","venue":"Nature Methods","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":425,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Transposable element; Biology; Caenorhabditis elegans; Sleeping Beauty transposon system; Genetics; Genome; Transgene; Transposase; Insertion; Caenorhabditis; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005713494,0.0001525263,0.0001984225,0.00007360608,0.00003806519,0.00001306052,0.00007902491,0.0004122453,0.000004634495],"category_scores_gemma":[0.0001092102,0.0001499117,0.00006096399,0.0001322361,0.00002579698,0.000003498041,0.00001147366,0.0002642694,1.217845e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000827165,"about_ca_system_score_gemma":0.00001724036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004152753,"about_ca_topic_score_gemma":0.00009150193,"domain_scores_codex":[0.9990215,0.0002259939,0.0001775289,0.0002958447,0.00007508408,0.0002040738],"domain_scores_gemma":[0.9996715,0.00003442911,0.00002563406,0.0001760074,0.00002923781,0.00006322261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001387082,0.00001544431,0.0002137391,0.0000315875,0.00001709713,0.000001152445,0.0001213589,0.004482397,0.9728514,0.00003149331,0.00001045065,0.02208517],"study_design_scores_gemma":[0.002306859,0.0001067906,0.004934217,0.00002204388,0.00003301381,0.00001792095,0.00002553657,0.0285293,0.9596703,0.000119644,0.00399264,0.0002417025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.516012,0.002871001,0.4807276,0.00004204942,0.0001237138,0.0001015792,0.000004881553,0.000008851963,0.0001083778],"genre_scores_gemma":[0.8729238,0.0001259556,0.126617,0.0001096557,0.0001298327,0.00000909649,0.00003545919,0.00002160888,0.00002760988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3569119,"threshold_uncertainty_score":0.611322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008783888759668653,"score_gpt":0.3617103949761183,"score_spread":0.3529265062164496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}