{"id":"W1979845492","doi":"10.1038/446975a","title":"When good drugs go bad","year":2007,"lang":"en","type":"article","venue":"Nature","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":282,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacogenomics; Drug reaction; Business; Adverse effect; Scale (ratio); Medicine; Drug; Geography; Psychiatry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006737675,0.0006203904,0.001491042,0.001896075,0.003202697,0.007783154,0.001036105,0.007577281,0.03057531],"category_scores_gemma":[0.02117253,0.0005764277,0.0008611932,0.00116656,0.009313021,0.007327778,0.003325677,0.00994573,0.01081619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003006149,"about_ca_system_score_gemma":0.004042696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002602961,"about_ca_topic_score_gemma":0.005681918,"domain_scores_codex":[0.9910297,0.002830048,0.0004648715,0.0006823394,0.003953004,0.001039992],"domain_scores_gemma":[0.988452,0.003777748,0.001589353,0.001148393,0.00255153,0.002481064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006409927,0.0002196707,0.01350193,0.0006425153,0.0002963112,0.001074015,0.0009494621,0.0002785528,0.002224326,0.1016911,0.6778641,0.200617],"study_design_scores_gemma":[0.0001138175,0.0002461582,0.007273789,0.0006852049,0.0001401916,0.001486771,0.001945309,0.000245311,0.002101007,0.1914596,0.7941816,0.0001213641],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01039811,0.03957646,0.002292982,0.7763739,0.01928673,0.0000526525,0.000736548,0.0003357863,0.1509469],"genre_scores_gemma":[0.268483,0.0470902,0.004194066,0.570778,0.01589211,0.0001559946,0.0006659004,0.0004857334,0.092255],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03057531,"threshold_uncertainty_score":0.1022846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0409152139193354,"score_gpt":0.4231492329399157,"score_spread":0.3822340190205803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}