{"id":"W1979845492","doi":"10.1038/446975a","title":"When good drugs go bad","year":2007,"lang":"en","type":"article","venue":"Nature","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":282,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacogenomics; Drug reaction; Business; Adverse effect; Scale (ratio); Medicine; Drug; Geography; Psychiatry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001443736,0.0002618503,0.0002507203,0.0001442621,0.0002175969,0.00002201585,0.0004616375,0.002495322,0.002771639],"category_scores_gemma":[0.00006903296,0.0002409127,0.0001460176,0.000249178,0.0001107113,0.00008641741,0.0001193529,0.00566146,0.0006997756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004533964,"about_ca_system_score_gemma":0.00006646596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005240852,"about_ca_topic_score_gemma":0.00001047574,"domain_scores_codex":[0.9981787,0.0001590473,0.0003123766,0.0003681353,0.0002881243,0.0006935811],"domain_scores_gemma":[0.9988097,0.0002810241,0.0001065594,0.0002546759,0.0001321261,0.0004159098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008028134,0.0008054404,0.0131621,0.00006681737,0.0005160214,0.0002930657,0.003814244,0.0000821366,0.2085487,0.03261649,0.3718662,0.367426],"study_design_scores_gemma":[0.001397222,0.00002217782,0.003902221,0.000004134615,0.0001161174,0.00001869659,0.00005686215,0.0001299162,0.1211258,0.002547196,0.87042,0.0002596365],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6357941,0.02233654,0.0002109524,0.004659307,0.008961026,0.0004941241,0.000130579,0.0002718876,0.3271415],"genre_scores_gemma":[0.9632471,0.0004378143,0.0008257068,0.02465617,0.001588553,0.00001023445,0.00003374576,0.00003940813,0.009161326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4985538,"threshold_uncertainty_score":0.9987996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0409152139193354,"score_gpt":0.4231492329399157,"score_spread":0.3822340190205803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}