{"id":"W1979854812","doi":"10.1016/j.bmcl.2014.10.004","title":"A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC− transporter","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency; TRIUMF","funders":"BC Cancer Agency; TRIUMF","keywords":"Chemistry; Oxidative stress; Transporter; Neurodegeneration; Pet imaging; Imaging agent; Biochemistry; Biomarker; Cystine; Positron emission tomography; In vivo; Cysteine; Neuroscience; Pathology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004920198,0.0008492323,0.0003732295,0.0003076381,0.0006283389,0.0004338107,0.001009933,0.001230119,0.004743045],"category_scores_gemma":[0.0003072092,0.0004922178,0.000363653,0.0002243193,0.0003422156,0.0005030684,0.0004812899,0.001506778,0.001461504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004819161,"about_ca_system_score_gemma":0.000772755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723505,"about_ca_topic_score_gemma":0.002706336,"domain_scores_codex":[0.9997912,0.00004754592,0.00001289766,0.00005748395,0.00004151548,0.00004940336],"domain_scores_gemma":[0.999877,0.00003406143,0.00002137107,0.00002783212,0.00001999223,0.00001973687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635937,0.00003931424,0.00004995945,0.0001033271,0.000009774009,0.0002242374,0.00003805009,0.0001795513,0.9927556,0.002160097,0.0004739419,0.003802597],"study_design_scores_gemma":[0.00004947658,0.0002045567,0.0002672621,0.00001305105,0.00001330311,0.0005948681,0.00001497305,0.0007424595,0.9858747,0.0003962517,0.01180686,0.00002212495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4506689,0.004877811,0.4999482,0.002088139,0.0005181243,0.001558487,0.00242803,0.001503205,0.03640908],"genre_scores_gemma":[0.7211009,0.003063553,0.2448975,0.0005074905,0.00007502782,0.001054792,0.001743089,0.0002368194,0.02732085],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004743045,"threshold_uncertainty_score":0.01586705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007771178940506545,"score_gpt":0.2322098813796895,"score_spread":0.2244387024391829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}